DOPE (GMP)
Based on 1 Customer Validation
DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 4004-05-1
- 分子式: C41H78NO8P
- 分子量:744.03
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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GPX4 |
ACSL4 |
FITC-labeled DOPE GMP (2 h) is internalized by IEC-6 rat intestinal epithelial cells within 2 hours, and fluorescence is detectable in both the cytoplasm and nucleus[1].
DOPE GMP (5 μg/mL; 1 h) restores the migratory capacity of IEC-6 rat intestinal epithelial cells inhibited by LPS[1].
DOPE GMP (5 μg/mL; 1 h) restores the migration and proliferation capacities, as well as the expression of tight junction proteins (ZO-1, occludin), in RSL3-induced ferroptotic rat intestinal epithelial cells IEC-6[1].
DOPE GMP enhances the uptake efficiency of mesenchymal stem cells for AMSC-MP, improves the cell adhesion ability to scaffolds, upregulates the expression of osteogenesis-related gene RUNX2, and enhances in vitro osteogenic differentiation capacity. Moreover, this formulation exhibits excellent biocompatibility and does not exert adverse effects on cell viability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-stimulated rat intestinal epithelial IEC-6 cells
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Concentration:5 µg/mL
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Incubation Time:1 h (pre-incubation); 6 h (scratch monitoring)
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Result:Restored LPS-inhibited IEC-6 cell migration capacity to near control levels, as measured by relative migration index.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (SD) Rat (neonatal, within 24 hours after birth, experimentally induced NEC)[1]
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Dosage:1 mg kg-1
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Administration:p.o.; 3 times daily; 4 days
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Result:Reduced neonatal rat mortality compared to the NEC-only group.
Significantly decreased the NEC pathological injury score of the terminal ileum.
Reduced relative mRNA expression of IL-1β and IL-6 in terminal ileum tissue.
Increased relative mRNA expression of tight junction proteins ZO-1 and occludin in terminal ileum tissue.
Improved intestinal epithelial proliferative ability compared to the NEC-only group.
Upregulated relative mRNA expression of the anti-ferroptosis factor GPX4 in terminal ileum tissue.
Reduced malondialdehyde (MDA) concentrations in terminal ileum tissue.
化学情報
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CAS 番号 4004-05-1
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分子量 744.03
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分子式 C41H78NO8P
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SMILES
O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
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別名
Dioleoylphosphatidylethanolamine (GMP); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Chen Y, et al. Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis. Food Funct. 2024;15(21):10811-10822. Published 2024 Oct 28. [Content Brief]
[4]. Cui GH, et al. RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease. Immun Ageing. 2019;16:10. Published 2019 May 13. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DOPE (GMP) 関連分類
HY-112005G 関連分類
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- DOPE (GMP)
- 4004-05-1
- Dioleoylphosphatidylethanolamine (GMP)
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP)
- Ferroptosis
- Glutathione Peroxidase
- ACSL Family
- Amino acid Transporter
- SLC7A11
- ACSL4
- Alzheimer’s disease
- neonatal SD rats
- tight junction proteins
- IEC-6 rat intestinal epithelial cells
- intestinal epithelial cells
- neonatal necrotizing enterocolitis
- GPX4
- ferroptosis
- Inhibitor
- inhibitor
- inhibit