DY3002
DY3002 is a selective and highly potent EGFR inhibitor with activity in overcoming T790M-mediated drug resistance in non-small cell lung cancer. DY3002 exhibited superior inhibitory effects against EGFR T790M mutants in kinase assays (IC50 = 0.71 nM), compared to weaker inhibitory effects against wild-type EGFR (IC50 = 448.7 nM). DY3002 was significantly superior to rociletinib and osimertinib in selectivity, showing an extremely high selectivity index (SI = 632.0). In cell experiments, DY3002 had an IC50 value of 0.037 μM against H1975 cells, showing enhanced inhibitory potency. In addition, DY3002 was superior to other alternative compounds in terms of biological properties and did not cause hyperglycemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2020015-37-4
- 分子式: C24H25ClN6O2
- 分子量:464.95
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
0.382 μM
Compound: 10c
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Antiproliferative activity against human A431 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A431 cells incubated for 72 hrs by MTT assay
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[PMID: 28395219] |
| A549 | IC50 |
4.45 μM
Compound: 10c
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Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
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[PMID: 28395219] |
| HCC827 | IC50 |
0.044 μM
Compound: 10c
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Antiproliferative activity against human HCC827 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCC827 cells incubated for 72 hrs by MTT assay
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[PMID: 28395219] |
| NCI-H1975 | IC50 |
0.037 μM
Compound: 10c
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Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
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[PMID: 28395219] |
化学情報
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CAS 番号 2020015-37-4
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分子量 464.95
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分子式 C24H25ClN6O2
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SMILES
C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(C=C3)CN4CCOCC4)=NC=C2Cl)=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DY3002 関連分類
HY-119396 関連分類
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