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製品番号: HY-183637

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E822-1968

E822-1968 is an UT-A2 inhibitor with a human IC₅₀ of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.

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CAS 番号: 1037259-63-4
分子式: C₁₉H₁₉N₃O₃
分子量:337.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

E822-1968 構造式

CAS 番号: 1037259-63-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

E822-1968 potently inhibits UT-A2-mediated urea transport in UT-A2-overexpressing HEK293F cells with an IC₅₀ of 0.44 μM^[1].
E822-1968 weakly inhibits UT-A3-mediated urea transport in UT-A3-overexpressing HEK293F cells with an IC₅₀ of 3.42 μM^[1].
E822-1968 (10 nM-100 μM; 50 seconds) does not inhibit UT-B-mediated urea transport in UT-B-overexpressing HEK293F cells^[1].
E822-1968 (1-10 μM; 30 minutes) does not inhibit rat UT-A1-mediated urea transport in stably expressing MDCK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1037259-63-4
分子量 337.37
分子式 C₁₉H₁₉N₃O₃
SMILES

COC1=CC(CNC(C2=CC(C3=CC=CC(OC)=C3)=NN2)=O)=CC=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Liu L, et al. Hotspot pocket-based discovery of urea transporter selective inhibitors. Nat Commun. Published online April 20, 2026. [Content Brief]

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