EFdA-TP tetralithium
Based on 1 publication(s) in Google Scholar
EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.91%
- 分子式: C12H11FLi4N5O12P3
- 分子量:556.93
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 EFdA-TP tetralithium
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生物活性
EFdA-TP (0.05-10 μM; for 15 min) tetralithium inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP tetralithium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator[1].
EFdA-TP tetralithium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 556.93
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分子式 C12H11FLi4N5O12P3
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Color White to off-white
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SMILES
O=[P](O[P](O[P](O[Li])(O[Li])=O)(O[Li])=O)(O[Li])OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
Structural and Mechanistic Basis of F227C-Mediated Hypersusceptibility to Islatravir in HIV-1 Reverse Transcriptase. [Abstract]2026 Jun 10:2026.06.08.730881. PMID: 42327331
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (179.56 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7956 mL | 8.9778 mL | 17.9556 mL | 44.8889 mL |
| 5 mM | 0.3591 mL | 1.7956 mL | 3.5911 mL | 8.9778 mL | |
| 10 mM | 0.1796 mL | 0.8978 mL | 1.7956 mL | 4.4889 mL | |
| 15 mM | 0.1197 mL | 0.5985 mL | 1.1970 mL | 2.9926 mL | |
| 20 mM | 0.0898 mL | 0.4489 mL | 0.8978 mL | 2.2444 mL | |
| 25 mM | 0.0718 mL | 0.3591 mL | 0.7182 mL | 1.7956 mL | |
| 30 mM | 0.0599 mL | 0.2993 mL | 0.5985 mL | 1.4963 mL | |
| 40 mM | 0.0449 mL | 0.2244 mL | 0.4489 mL | 1.1222 mL | |
| 50 mM | 0.0359 mL | 0.1796 mL | 0.3591 mL | 0.8978 mL | |
| 60 mM | 0.0299 mL | 0.1496 mL | 0.2993 mL | 0.7481 mL | |
| 80 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5611 mL | |
| 100 mM | 0.0180 mL | 0.0898 mL | 0.1796 mL | 0.4489 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
EFdA-TP tetralithium 関連分類
HY-138561C 関連分類
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