EJMC-1
Based on 1 Customer Validation
EJMC-1 is a moderately potent TNF-α inhibitor with an IC50 value of 42 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.08%
- CAS 番号: 397281-20-8
- 分子式: C17H11ClN2O4S
- 分子量:374.80
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
42.3 μM
Compound: 1
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Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay system
Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay system
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[PMID: 25078315] |
| HeLa | IC50 |
45.7 μM
Compound: 1
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Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA
Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA
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[PMID: 25078315] |
化学情報
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CAS 番号 397281-20-8
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性状 Solid
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分子量 374.80
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分子式 C17H11ClN2O4S
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Color Light yellow to yellow
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SMILES
O=C1NC2=CC=C(S(=O)(NC3=CC=C(C(Cl)=C3)O)=O)C4=C2C1=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (333.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6681 mL | 13.3404 mL | 26.6809 mL | 66.7022 mL |
| 5 mM | 0.5336 mL | 2.6681 mL | 5.3362 mL | 13.3404 mL | |
| 10 mM | 0.2668 mL | 1.3340 mL | 2.6681 mL | 6.6702 mL | |
| 15 mM | 0.1779 mL | 0.8894 mL | 1.7787 mL | 4.4468 mL | |
| 20 mM | 0.1334 mL | 0.6670 mL | 1.3340 mL | 3.3351 mL | |
| 25 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6681 mL | |
| 30 mM | 0.0889 mL | 0.4447 mL | 0.8894 mL | 2.2234 mL | |
| 40 mM | 0.0667 mL | 0.3335 mL | 0.6670 mL | 1.6676 mL | |
| 50 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 60 mM | 0.0445 mL | 0.2223 mL | 0.4447 mL | 1.1117 mL | |
| 80 mM | 0.0334 mL | 0.1668 mL | 0.3335 mL | 0.8338 mL | |
| 100 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6670 mL |
EJMC-1 関連分類
HY-147078 関連分類
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