Euxanthone
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Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.96%
- CAS 番号: 529-61-3
- 分子式: C13H8O4
- 分子量:228.20
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>200 μM
Compound: 8
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Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay
Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay
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[PMID: 28065566] |
| A549 | IC50 |
14.5 mg/mL
Compound: 13
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Cytotoxicity against human A549 cells after 3 days by SRB assay
Cytotoxicity against human A549 cells after 3 days by SRB assay
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[PMID: 15568778] |
| HeLa S3 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| HepG2 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| HT-29 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| KB | IC50 |
>10 μM
Compound: 19
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Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| MCF7 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
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[PMID: 30978023] |
| MCF7 | IC50 |
19.5 mg/mL
Compound: 13
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Cytotoxicity against human MCF7 cells after 3 days by SRB assay
Cytotoxicity against human MCF7 cells after 3 days by SRB assay
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[PMID: 15568778] |
| NCI/ADR-RES | IC50 |
>200 μM
Compound: 8
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Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay
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[PMID: 28065566] |
| OVCAR-3 | IC50 |
>10 μM
Compound: 27
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Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
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[PMID: 30830783] |
| SK-OV-3 | IC50 |
>10 μM
Compound: 27
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Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
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[PMID: 30830783] |
| SMMC-7721 | IC50 |
60.35 μM
Compound: 8
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Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay
Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay
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[PMID: 28065566] |
体外実験
Euxanthone (10-20 μM; 24 h) compromises the capability of OS cells to migrate in a dose-dependent fashion, and significantly suppresses cell invasion. Euxanthone presents a significant decrease in adhesion to fibronectin[1].
Euxanthone (10-20 μM; 24 h) modulates the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway. The repression of COX-2 by Euxanthone mediated its anti-metastatic activities[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Osteosarcoma (OS) cells
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Concentration:10 μM, 20 μM
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Incubation Time:24 h
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Result:Inhibited cell migration at 24 hr.
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Cell Line:Osteosarcoma (OS) cells
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Concentration:10 μM, 20 μM
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Incubation Time:24 h
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Result:Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
体内実験
Euxanthone (30-60 mg/kg; p.o.;once a day; for 7 days) treatment normalized Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I in bearing bilateral common carotid artery occlusion (BCCAO). Euxanthone modulates mitophagy and apoptosis induces by mitochondrial stress mediated by mitochondrial fragmentation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2]
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Dosage:30 mg/kg, 60 mg/kg
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Administration:p.o.;once a day; for 7 days
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Result:Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
化学情報
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CAS 番号 529-61-3
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性状 Solid
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分子量 228.20
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分子式 C13H8O4
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Color Light yellow to yellow
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SMILES
O=C1C2=C(OC3=C1C=C(O)C=C3)C=CC=C2O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. [Content Brief]
[2]. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. [Content Brief]
[3]. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Euxanthone 関連分類
HY-N3883 関連分類
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