FBP
FBP is a mitochondria-targeted, selective anticancer agent. FBP induces oxidative stress and mitochondrial dysfunction, leading to Apoptosis. FBP generates ROS and causes double-strand DNA breaks in cancer cells. FBP exhibits cytotoxic efficacy against cancer cells, with cervical cancer cells being the most sensitive. FBP can be used for the research of cervical cancer, lung cancer, melanoma and breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C24H22FeIN3
- 分子量:535.20
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
製品説明
体外実験
FBP (50-500 μg/mL; 24 h) exhibits excellent biocompatibility with NIH3/T3 mouse embryonic fibroblasts and L929 mouse fibroblasts[1].
FBP (50-500 μg/mL; 24 h) exhibits selective concentration-dependent cytotoxicity against a variety of cancer cell lines, with the strongest activity against HeLa cervical cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH3/T3 mouse embryonic fibroblasts, L929 mouse fibroblasts
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Concentration:50-500 μg/mL
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Incubation Time:24 h
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Result:Maintained cell viability above 80% at concentrations up to 200 μg/mL in both cell lines.
Reached an IC50 greater than 220 μg/mL for L929 cells.
Reached an IC50 greater than 290 μg/mL for NIH3/T3 cells.
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Cell Line:HeLa human cervical carcinoma cells, A549 human lung adenocarcinoma cells, B16F10 mouse melanoma cells, 4T1 murine mammary carcinoma cells
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Concentration:50-500 μg/mL
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Incubation Time:24 h
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Result:Induced concentration-dependent reductions in cell viability across all tested cancer cell lines.
Showed the highest sensitivity against HeLa cells, with an IC50 of 180 μg/mL and a selectivity index of 1.61 relative to NIH3/T3 cells.
Reached an IC50 of 290 μg/mL and a selectivity index of 1 against A549 cells.
Reached an IC50 of 240 μg/mL and a selectivity index of 1.20 relative to NIH3/T3 cells against B16F10 and 4T1 cells.
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- ROS/oxidative-stress fluorescent staining
- Mitochondrial membrane-potential and mitochondrial mass staining
- Apoptosis Solutions
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
化学情報
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分子量 535.20
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分子式 C24H22FeIN3
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SMILES
[][Fe][].c1(C[N+]2=CN(Cc3ncccc3)C4=CC=CC=C42)cccc1.c5cccc5.[I-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FBP 関連分類
HY-182266 関連分類
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Keywords
- FBP
- Mitochondrial Metabolism
- Apoptosis
- Reactive Oxygen Species (ROS)
- DNA/RNA Synthesis
- NIH3/T3 mouse embryonic fibroblasts
- reactive oxygen species
- HeLa human cervical carcinoma cells
- apoptotic cell death
- singlet oxygen
- A549 human lung adenocarcinoma cells
- B16F10 mouse melanoma
- DNA double-strand breaks
- L929 mouse fibroblasts
- mitochondria
- Inhibitor
- inhibitor
- inhibit