FKB04
Based on 1 Customer Validation
FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.98%
- CAS 番号: 108979-07-3
- 分子式: C17H15BrO4
- 分子量:363.20
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Liver Cancer Compound Library
HY-L101
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
Telomere repeat binding factor 2 (TRF2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.3 μM
Compound: 10f
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Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
Inhibition of TNFalpha induced NF-kappaB activation in human A549 cells by luciferase reporter gene assay
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[PMID: 19883086] |
| NIH3T3 | IC50 |
2.2 μM
Compound: 2g
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Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay
Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay
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[PMID: 21112783] |
化学情報
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CAS 番号 108979-07-3
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性状 Solid
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分子量 363.20
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分子式 C17H15BrO4
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Color Light yellow to yellow
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SMILES
BrC1=CC(/C=C/C(C2=C(C=C(C=C2O)OC)OC)=O)=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (275.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7533 mL | 13.7665 mL | 27.5330 mL | 68.8326 mL |
| 5 mM | 0.5507 mL | 2.7533 mL | 5.5066 mL | 13.7665 mL | |
| 10 mM | 0.2753 mL | 1.3767 mL | 2.7533 mL | 6.8833 mL | |
| 15 mM | 0.1836 mL | 0.9178 mL | 1.8355 mL | 4.5888 mL | |
| 20 mM | 0.1377 mL | 0.6883 mL | 1.3767 mL | 3.4416 mL | |
| 25 mM | 0.1101 mL | 0.5507 mL | 1.1013 mL | 2.7533 mL | |
| 30 mM | 0.0918 mL | 0.4589 mL | 0.9178 mL | 2.2944 mL | |
| 40 mM | 0.0688 mL | 0.3442 mL | 0.6883 mL | 1.7208 mL | |
| 50 mM | 0.0551 mL | 0.2753 mL | 0.5507 mL | 1.3767 mL | |
| 60 mM | 0.0459 mL | 0.2294 mL | 0.4589 mL | 1.1472 mL | |
| 80 mM | 0.0344 mL | 0.1721 mL | 0.3442 mL | 0.8604 mL | |
| 100 mM | 0.0275 mL | 0.1377 mL | 0.2753 mL | 0.6883 mL |
FKB04 関連分類
HY-169120 関連分類
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