FSHR agonist 1
Based on 1 Customer Validation
FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.45%
- CAS 番号: 1256776-89-2
- 分子式: C26H33N3O3S
- 分子量:467.62
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
pEC50: 7.72 (FSHR)[1]
The binding of FSHR agonist 1 (compound 21f) to the FSHR TMD pocket induces inward movements of TM6 and TM7, which directly results in FSHR activation[1].
FSHR agonist 1 (compound 21f) can activate FSHR, LHCGR and TSHR with highly potency and efficacy, while the activation potency for FSHR is more than 10-fold higher than LHCGR (pEC50 of 6.26) and TSHR (pEC50 of 6.48)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1256776-89-2
-
性状 Solid
-
分子量 467.62
-
分子式 C26H33N3O3S
-
Color White to light yellow
-
SMILES
O=C(N(C(C)(C)C)CC)C1=NC(C2=CC=CS2)=C3C4=C(CCN13)C=C(OC)C(OC(C)C)=C4
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (106.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (277 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1385 mL | 10.6924 mL | 21.3849 mL | 53.4622 mL |
| 5 mM | 0.4277 mL | 2.1385 mL | 4.2770 mL | 10.6924 mL | |
| 10 mM | 0.2138 mL | 1.0692 mL | 2.1385 mL | 5.3462 mL | |
| 15 mM | 0.1426 mL | 0.7128 mL | 1.4257 mL | 3.5641 mL | |
| 20 mM | 0.1069 mL | 0.5346 mL | 1.0692 mL | 2.6731 mL | |
| 25 mM | 0.0855 mL | 0.4277 mL | 0.8554 mL | 2.1385 mL | |
| 30 mM | 0.0713 mL | 0.3564 mL | 0.7128 mL | 1.7821 mL | |
| 40 mM | 0.0535 mL | 0.2673 mL | 0.5346 mL | 1.3366 mL | |
| 50 mM | 0.0428 mL | 0.2138 mL | 0.4277 mL | 1.0692 mL | |
| 60 mM | 0.0356 mL | 0.1782 mL | 0.3564 mL | 0.8910 mL | |
| 80 mM | 0.0267 mL | 0.1337 mL | 0.2673 mL | 0.6683 mL | |
| 100 mM | 0.0214 mL | 0.1069 mL | 0.2138 mL | 0.5346 mL |
FSHR agonist 1 関連分類
HY-150210 関連分類
Powered by Bioz