Fumitremorgin B
Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL.
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- CAS 番号: 12626-17-4
- 分子式: C27H33N3O5
- 分子量:479.57
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保管条件:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
fungal[3]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 27865702] |
| HT-29 | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 27865702] |
| Jurkat | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
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[PMID: 27865702] |
| MCF7 | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 27865702] |
| PC-3 | IC50 |
43.36 μM
Compound: 574
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Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38181652] |
| U-937 | IC50 |
14.12 μM
Compound: 574
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Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38181652] |
Fumitremorgin B (3 or 4 days) inhibits the proliferation of U937 and PC3 cells, with IC50 of 14.12 and 43.36 μM, respectively[2].
Fumitremorgin B exhibits antifungal activities against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum f. sp. niveum, F. oxysporum f. sp. vasinfectum, and G. saubinettii, with MICs of 6.25-50 μg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 12626-17-4
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性状 Oil
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分子量 479.57
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分子式 C27H33N3O5
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Color Off-white to light brown
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SMILES
O=C([C@]1(O)[C@@H](O)C2=C([C@H](/C=C(C)\C)N13)N(C/C=C(C)\C)C4=C2C=CC(OC)=C4)N5[C@](CCC5)([H])C3=O
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Structure Classification
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Initial Source
fungus Aspergillus fumigatus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li SM, et, al. Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes. J Antibiot (Tokyo). 2011 Jan;64(1):45-9. [Content Brief]
[2]. Wang Y, et, al. 2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7. Chem Biodivers. 2012 Feb;9(2):385-93. [Content Brief]
[3]. Li XJ, et, al. Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities. J Agric Food Chem. 2012 Apr 4;60(13):3424-31. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Fumitremorgin B 関連分類
HY-117313 関連分類
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