country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-108024B

Copy Link Print Information

Ganaplacide phosphate

(別名: KAF156 phosphate; GNF156 phosphate)

Ganaplacide (KAF156) phosphate is an orally active imidazolopiperazine antimalarial agent. Ganaplacide phosphate is active against a broad range of Plasmodium species, including agent-resistant parasites. Ganaplacide phosphate is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3051901-82-4
分子式: C₂₂H₂₉F₂N₅O₉P₂
分子量:607.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ganaplacide phosphate 構造式

CAS 番号: 3051901-82-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

Ganaplacide phosphate shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM against P. falciparum agent-sensitive and agent-resistant strains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Ganaplacide (1-15 mg/kg; p.o.) phosphate is fully protective in a causal prophylactic mouse model of malaria^[1]. Ganaplacide phosphate displays cidal activity against mature Plasmodium falciparum gametocytes and thus blocks parasite transmission to Anopheles mosquitoes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice (causal prophylactic rodent malaria model)^[1]
Dosage:

1-15 mg/kg
Administration:

p.o.
Result:

Was fully protective (a single oral dose of 10 mg of KAF156/kg administered 2 h before infection).

化学情報

CAS 番号 3051901-82-4
分子量 607.44
分子式 C₂₂H₂₉F₂N₅O₉P₂
SMILES

O=C(CN)N1CCN2C(C1(C)C)=NC(C3=CC=C(C=C3)F)=C2NC4=CC=C(C=C4)F.O=P(O)(O)O.O=P(O)(O)O
別名

KAF156 phosphate; GNF156 phosphate
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kuhen KL, et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob Agents Chemother. 2014;58(9):5060-5067. [Content Brief]

[2]. Leong FJ, et al. A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers. Antimicrob Agents Chemother. 2014;58(11):6437-6443. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Ganaplacide phosphate

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Ganaplacide phosphate 関連分類

HY-108024B 関連分類