GCS-12–6
GCS-12-6 is a potent Th2-selective NKT cell agonist targeting the CD1d protein. GCS-12-6 mediates the rapid presentation of glycolipid/CD1d complexes on the surface of antigen-presenting cells. GCS-12-6 holds promise for research on autoimmune diseases (such as inflammatory bowel disease and multiple sclerosis).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C42H84N2O11S
- 分子量:825.19
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[2]|
CD1d |
IL-4 |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse splenocytes
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Concentration:10, 100, 1000 nM
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Incubation Time:72 h
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Result:Did not exhibit apparent cytotoxicity at any of the tested concentrations, and the cell viability remained at a very high level.
体内実験
GCS-12-6 (1 μg; i.p.; administered on days 2 and 4 of the experiment, twice in total; observation until day 8) significantly alleviates colonic inflammation, reduces the disease activity index, protects colonic length, and prevents body weight loss in the DSS (HY-116282C)-induced C57BL/6 mouse colitis model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 6-8 weeks old)[2]
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Dosage:1 μg
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Administration:i.p.; on days 2 and 4; 8 days
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Result:Alleviated the body weight loss induced by DSS and significantly reduced the disease activity index (DAI) scores.
Dissection showed that colon shortening was significantly protected, and histopathological (H&E staining) results indicated that it could effectively alleviate the destruction of intestinal crypts and the infiltration of inflammatory cells.
化学情報
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分子量 825.19
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分子式 C42H84N2O11S
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SMILES
O[C@@H]([C@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(CCCCCCCCCCCNS(=O)(CCCCCC)=O)=O)[C@@H](CCCCCCCCCCCCCC)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GCS-12–6 関連分類
HY-175365 関連分類
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