Gpr119 - G-protein coupled receptor 119 Gene

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 236781

About Gpr119

Chromosome X: 47,756,856-47,763,355 reverse strand.GRCm39:CM001013.3

This gene has 1 transcript (splice variant), 176 orthologues, 18 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

Enables phosphatidylcholine binding activity. Acts upstream of or within Insulin secretion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in colon and ileum. Orthologous to human GPR119 (G protein-coupled receptor 119). [provided by Alliance of Genome Resources, Apr 2022]

Gpr119 Products (1)

mRNA Protein Name
NM_181751.2 NP_861416.1 glucose-dependent insulinotropic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphatidylcholine binding IDA
IDA: Inferred from direct assay
15607732 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within insulin secretion IDA
IDA: Inferred from direct assay
15607732 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr119 Protein Structure

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (5 - 289)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (6 - 31)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (39 - 65)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (77 - 107)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (119 - 139)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (161 - 190)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (217 - 247)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (257 - 282)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

glucose-dependent insulinotropic receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
製品番号 製品名 製品効果
純度 Phase
HY-15291 MBX-2982 Agonist 99.68% Phase 2
HY-12066 GSK1292263 Agonist 99.71% Phase 2
HY-109032 Firuglipel Agonist 99.91% Phase 2
HY-171454 DA-1241 Agonist 99.18% Phase 2
HY-178780 Deziglipel Agonist 98.06% Phase 2
HY-175422 K-833 Agonist / Phase 2
HY-15565 APD668 Agonist 99.73% Phase 1
HY-15566 APD597 Agonist 99.97% Phase 1
HY-12375 BMS-903452 Agonist 99.70% Phase 1

Pre-clinical Phase

Bioactive Molecules (24)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-W011121 2-Oleoylglycerol Agonist 99.9% Unkown
HY-15564 AR 231453 Agonist 99.58% Unkown
HY-107535 AS1269574 Agonist 99.84% Unkown
HY-16673 PSN632408 Agonist 99.30% Unkown
HY-108258 PSN 375963 Agonist 99.95% Unkown
HY-120637 BMS-986034 Agonist / Unkown
HY-W701772 2-Oleoylglycerol-d5 / Unkown
HY-182454 GPR119 agonist 4 Agonist / Unkown
HY-155553 GPR119 agonist 2 Agonist / Unkown
HY-146468 DPP-4/GPR119 modulator 1 Agonist / Unkown
HY-126807 AS1907417 Agonist / Unkown
HY-113653 GSK2041706A Agonist / Unkown
HY-115643 AZ13581837 Agonist / Unkown
HY-172120 GPR119 agonist 3 Agonist / Unkown
HY-108258A PSN 375963 hydrochloride Agonist / Unkown
HY-182580 HBK001 Agonist / Unkown
HY-146469 DPP-4/GPR119 modulator 2 Agonist / Unkown
HY-124978 MK-8282 Agonist / Unkown
HY-125646 YH18968 Activator / Unkown
HY-18354 GSK1104252A Activator / Unkown
HY-12066A GSK-1292263 hydrochloride Agonist / Unkown
HY-113243 1-Oleoyl lysophosphatidylcholine Activator 95.0% Unkown
HY-117446A AS-1669058 free base Agonist / Unkown
HY-117446 AS-1669058 Agonist / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Gpr119 NCBI NCBI:139760