PDIA3 - protein disulfide isomerase family A member 3 Gene

Also Known as P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 2923

About PDIA3

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,746,438-43,773,278 (from NCBI)

This gene has 33 transcripts (splice variants), 222 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 333.0), prostate (RPKM 175.9) and 25 other tissues.

Summary

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates. [provided by RefSeq, Dec 2016]

PDIA3 Products (2)

mRNA Protein Name
NM_005313.5 NP_005304.3 protein disulfide-isomerase A3 precursor
NM_005313.5 NP_005304.3 protein disulfide-isomerase A3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IPI
IPI: Inferred from physical interaction
16905107 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15896298 GOA
enables protein-disulfide reductase activity IDA
IDA: Inferred from direct assay
16677074 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in peptide antigen assembly with MHC class I protein complex IDA
IDA: Inferred from direct assay
17603487 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of MHC class I peptide loading complex IDA
IDA: Inferred from direct assay
17947644 GOA
part of Tapasin-ERp57 complex IPI
IPI: Inferred from physical interaction
19119025 GOA
located in cell surface IDA
IDA: Inferred from direct assay
19995400 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23826168 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
19995400 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA3 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (27 - 131)

Thioredoxin_6

Thioredoxin_6: Thioredoxin-like domain (160 - 355)

Thioredoxin

Thioredoxin: Thioredoxin (378 - 482)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

protein disulfide-isomerase A3

  • 58 kDa glucose-regulated protein

  • 58 kDa microsomal protein

  • ER protein 57

  • ER protein 60

  • disulfide isomerase ER-60

  • endoplasmic reticulum P58

  • endoplasmic reticulum resident protein 57

  • endoplasmic reticulum resident protein 60

  • epididymis secretory protein Li 269

  • epididymis secretory sperm binding protein Li 93n

  • glucose regulated protein, 58kDa

  • phospholipase C-alpha

  • protein disulfide isomerase-associated 3

PDIA3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PDIA3 P30101 PRDX4 Homo sapiens Q13162
Enzymatic Study
21057456
Intra
PDIA3 P30101 STIM1 Homo sapiens Q13586
SPR
21941299
Intra
PDIA3 P30101 STIM1 Homo sapiens Q13586
IF
21941299
Intra
PDIA3 P30101 APP Homo sapiens P05067
Pull Down
15896298
Cross
PDIA3 P30101 CANX Canis familiaris P24643
NMR
16905107
Cross
PDIA3 P30101 CANX Canis familiaris P24643
ITC
16905107
Cross
PDIA3 P30101 Calr Rattus norvegicus P18418
Pull Down
22665516
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDIA3 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71148 PDIA3 Protein, Human (HEK293, His) P30101 (S25-L505) ≥ 90%, as determined by reducing SDS-PAGE.

PDIA3 抗体

製品番号 製品名 アプリケーション 反応性
HY-P83555 ERp57 Antibody (YA3300) WB, IHC-P, IP Human

関連疾患

Diseases Alias
Granulomatous Orchitis

  • Non-Specific Granulomatous Orchitis
Macular Degeneration, Age-Related, 15

  • Age Related Macular Degeneration 15

  • ARMD15

  • Macular Degeneration, Age-Related, 15, Susceptibility To

  • Macular Degeneration, Age-Related, Type 15
Creutzfeldt-Jakob Disease

  • Variant Creutzfeldt-Jakob Disease

  • CJD

  • Bovine Spongiform Encephalopathy

  • Vcjd

  • Inherited Creutzfeldt-Jakob Disease

  • Creutzfeldt-Jakob Disease, Familial

  • Creutzfeldt Jakob Disease

  • Creutzfeldt-Jacob Disease

  • Creutzfeldt Jacob Disease

  • Sporadic Creutzfeldt-Jakob Disease

  • Encephalopathy, Bovine Spongiform

  • Creutzfeldt-Jakob Disease, Variant, Resistance To

  • Creutzfeldt-Jakob Disease, Variant

  • Creutzfeldt Jacob Syndrome

  • Jakob-Creutzfeldt Disease

  • Subacute Spongiform Encephalopathy

  • Transmissible Virus Dementia

  • New Variant Of Cjd

  • Nv-Cjd

  • Variant Cjd

  • Variant Creutzfeldt-Jacob Disease

  • Sporadic Cjd

  • Inherited Cjd

  • Acquired Creutzfeldt-Jakob Disease

  • Variant Mcj

  • Encephalopathy Bovine Spongiform

  • Familial Creutzfeldt-Jakob Disease

  • Creutzfeldt-Jakob Syndrome

  • New Variant Creutzfeldt-Jakob Disease

  • Creutzfeldt-Jakob Disease, Sporadic

  • Acquired Cjd

  • Scjd - [Sporadic Creutzfeldt-Jakob Disease]

  • Idiopathic Creutzfeldt-Jakob Disease

  • Creutzfeld-Jakob Disease Nos

  • Vcjd - [Variant Creutzfeldt-Jakob Disease]
Prion Disease

  • Spongiform Encephalopathy

  • Transmissible Spongiform Encephalopathies

  • Prion Diseases

  • Prion Disease Pathway

  • Transmissible Spongiform Encephalopathy

  • Prion Induced Disorder

  • Prion Protein Disease

  • Inherited Human Transmissible Spongiform Encephalopathies

  • Prion Protein Diseases

  • Prion-Associated Disorders

  • Prion-Induced Disorders

  • Transmissible Dementias

  • Tses

  • Human Prion Disease

  • Tse

  • Encephalopathy, Transmissible Spongiform

  • Prion Disease, Susceptibility To

  • Spongiform Encephalopathies

  • Human Transmissible Spongiform Encephalopathies, Inherited
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-N0177 Diosgenin Inhibitor 99.92% Unkown
HY-100432 LOC14 98.0% Unkown
HY-122895 E64FC26 98.48% Unkown
HY-122895A (E/Z)-E64FC26 99.80% Unkown
HY-RS10266 PDIA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10267 Pdia3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151286 Antitumor agent-73 Inhibitor / Unkown
HY-170655 PDI-IN-4 Inhibitor / Unkown
HY-P11857 Alkyne-GRWHPM-CONH-NH-CMK Inhibitor / Unkown
HY-RS10268 Pdia3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus PDIA3 VGNC VGNC:67483
Mus musculus PDIA3 MGD MGI:95834
Bos taurus PDIA3 VGNC VGNC:32697
Canis familiaris PDIA3 VGNC VGNC:103695
Rattus norvegicus PDIA3 RGD RGD:68430
Macaca mulatta PDIA3 VGNC VGNC:75905
Others PDIA3 NCBI