CNOT7 - CCR4-NOT transcription complex subunit 7 Gene

Also Known as CAF1; CAF-1; Caf1a; hCAF-1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 29883

About CNOT7

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,224,966-17,246,857 (from NCBI)

This gene has 13 transcripts (splice variants), 222 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

CNOT7 Products (16)

mRNA Protein Name
NM_001322087.2 NP_001309016.1 CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322088.2 NP_001309017.1 CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322089.2 NP_001309018.1 CCR4-NOT transcription complex subunit 7 isoform 2
NM_001322090.2 NP_001309019.1 CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322091.2 NP_001309020.1 CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322092.2 NP_001309021.1 CCR4-NOT transcription complex subunit 7 isoform 1
NM_001322093.2 NP_001309022.1 CCR4-NOT transcription complex subunit 7 isoform 3
NM_001322094.2 NP_001309023.1 CCR4-NOT transcription complex subunit 7 isoform 4
NM_001322095.2 NP_001309024.1 CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322096.2 NP_001309025.1 CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322097.2 NP_001309026.1 CCR4-NOT transcription complex subunit 7 isoform 5
NM_001322098.2 NP_001309027.1 CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322099.2 NP_001309028.1 CCR4-NOT transcription complex subunit 7 isoform 6
NM_001322100.2 NP_001309029.1 CCR4-NOT transcription complex subunit 7 isoform 6
NM_013354.7 NP_037486.2 CCR4-NOT transcription complex subunit 7 isoform 1
NM_054026.4 NP_473367.2 CCR4-NOT transcription complex subunit 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
15769875 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
23386060 GOA
enables RNA exonuclease activity IDA
IDA: Inferred from direct assay
19276069 GOA
enables poly(A)-specific ribonuclease activity IDA
IDA: Inferred from direct assay
15769875 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9820826 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
23386060 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
IDA: Inferred from direct assay
31439799 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
23386060 GOA
involved in miRNA-mediated gene silencing by mRNA destabilization IDA
IDA: Inferred from direct assay
20065043 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
23386060 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19276069 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25038453 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
23386060 GOA
involved in nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
21336257 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19605561 GOA
involved in positive regulation of mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
23386060 GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
IMP: Inferred from mutant phenotype
21278420 GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
IMP: Inferred from mutant phenotype
21278420 GOA
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
23386060 GOA
involved in regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
23386060 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
19558367 GOA
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
23386060 GOA
is active in intracellular non-membrane-bounded organelle IDA
IDA: Inferred from direct assay
31439799 GOA
located in nuclear speck IMP
IMP: Inferred from mutant phenotype
23386060 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9820826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT7 Protein Structure

CAF1

CAF1: CAF1 family ribonuclease (14 - 240)

  • 0
  • 100
  • 200
  • 285 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 7

  • BTG1-binding factor 1

CNOT7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CNOT7 Q9UIV1 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
28514442
Intra
CNOT7 Q9UIV1 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
33961781
Intra
CNOT7 Q9UIV1 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
17452450
Intra
CNOT7 Q9UIV1 CNOT1 Homo sapiens A5YKK6
GMS
22977175
Intra
CNOT7 Q9UIV1 CNOT1 Homo sapiens A5YKK6
Pull Down
22977175
Intra
CNOT7 Q9UIV1 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
22977175
Intra
CNOT7 Q9UIV1 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
33961781
Intra
CNOT7 Q9UIV1 CNOT6 Homo sapiens Q9ULM6
Anti Tag CoIP
33961781
Intra
CNOT7 Q9UIV1 TOB2 Homo sapiens Q14106
Anti Tag CoIP
28514442
Intra
CNOT7 Q9UIV1 TOB2 Homo sapiens Q14106
Y2H Array
25416956
Intra
CNOT7 Q9UIV1 TOB2 Homo sapiens Q14106
Anti Tag CoIP
33961781
Intra
CNOT7 Q9UIV1 TOB2 Homo sapiens Q14106
Validated Y2H
25416956
Intra
CNOT7 Q9UIV1 PATL1 Homo sapiens Q86TB9
Anti Tag CoIP
20584987
Intra
CNOT7 Q9UIV1 AGO2 Homo sapiens Q9UKV8
Anti Tag CoIP
21981923
Intra
CNOT7 Q9UIV1 TOB1 Homo sapiens P50616
X-Ray Diffraction
19276069
Intra
CNOT7 Q9UIV1 TOB1 Homo sapiens P50616
Y2H Array
31515488
Intra
CNOT7 Q9UIV1 TOB1 Homo sapiens P50616
Anti Tag CoIP
33961781
Intra
CNOT7 Q9UIV1 TOB1 Homo sapiens P50616
ITC
20595394
Intra
CNOT7 Q9UIV1 TOB1 Homo sapiens P50616
Anti Tag CoIP
28514442
Intra
CNOT7 Q9UIV1 TOB1 Homo sapiens P50616
Anti Tag CoIP
21336257
Intra
CNOT7 Q9UIV1 TOB1 Homo sapiens P50616
TAP
18377426
Intra
CNOT7 Q9UIV1 BTG1 Homo sapiens P62324
Y2H
11136725
Cross: Cross-species interaction Intra: Intraspecies interaction

CNOT7 抗体

製品番号 製品名 アプリケーション 反応性
HY-P811145 CNOT7 Antibody WB, IHC-P Human, Mouse, Rat
HY-P86816 CNOT7 Antibody (YA6509) WB, ICC/IF, FC Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS02907 CNOT7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22451 Cnot7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28974 Cnot7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus CNOT7 VGNC VGNC:61030
Canis familiaris CNOT7 VGNC VGNC:39418
Rattus norvegicus CNOT7 RGD RGD:1305313
Mus musculus CNOT7 MGD MGI:1298230
Macaca mulatta CNOT7 VGNC VGNC:83990
Bos taurus CNOT7 VGNC VGNC:27522
Others CNOT7 NCBI