Sphk2 - sphingosine kinase 2 Gene

Also Known as Sk2; Spk2

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 56632

About Sphk2

Chromosome 7: 45,358,891-45,367,426 reverse strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 209 orthologues, 4 paralogues and is associated with 5 phenotypes. Ubiquitous expression in duodenum adult (RPKM 72.1), adrenal adult (RPKM 42.9) and 28 other tissues.

Summary

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and Apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances Apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Sphk2 Products (3)

mRNA Protein Name
NM_203280.3 NP_975009.1 sphingosine kinase 2
NM_020011.5 NP_064395.2 sphingosine kinase 2
NM_001172561.1 NP_001166032.1 sphingosine kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables D-erythro-sphingosine kinase activity IDA
IDA: Inferred from direct assay
10751414 MGI
enables D-erythro-sphingosine kinase activity IMP
IMP: Inferred from mutant phenotype
16093248 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16316995 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within blood vessel development IGI
IGI: Inferred from genetic interaction
16314531 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
16314531 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16314531 MGI
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
16118219 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
16118219 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
16314531 MGI
involved in positive regulation of ceramide biosynthetic process IDA
IDA: Inferred from direct assay
16118219 MGI
involved in positive regulation of cytokine production involved in immune response IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in positive regulation of interleukin-13 production IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in positive regulation of mast cell activation involved in immune response IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
25637806 MGI
involved in regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
17346996 MGI
involved in regulation of cytochrome-c oxidase activity IMP
IMP: Inferred from mutant phenotype
20959514 MGI
involved in regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
25637806 MGI
involved in sphinganine-1-phosphate biosynthetic process IDA
IDA: Inferred from direct assay
10751414 MGI
acts upstream of or within sphingosine metabolic process IMP
IMP: Inferred from mutant phenotype
16093248 MGI
involved in sphingosine metabolic process IMP
IMP: Inferred from mutant phenotype
17346996 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
16118219 MGI
located in cytosol IDA
IDA: Inferred from direct assay
10751414 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16118219 MGI
located in membrane IDA
IDA: Inferred from direct assay
10751414 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
20959514 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
25637806 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20959514 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sphk2 Protein Structure

PLN02958

PLN02958: cl29912 (141 - 607)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
Protein Preferred Names Protein Names

sphingosine kinase 2

Sphk2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
Sphk2 Q9JIA7 Fyn Mus musculus P39688
Anti Bait CoIP
16316995
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-15779A K145 hydrochloride Inhibitor 99.63% Unkown
HY-12892 SKI-178 Inhibitor 99.29% Unkown
HY-147282 Amgen-23 Inhibitor 98.11% Unkown
HY-148707 SphK1&2-IN-1 Inhibitor 98.47% Unkown
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% Unkown
HY-151350 SphK2-IN-1 Inhibitor 99.61% Unkown
HY-150615 SphK1-IN-2 Inhibitor / Unkown
HY-120440 VT-ME6 Inhibitor / Unkown
HY-112385 ABC294735 Inhibitor / Unkown
HY-12896 SLR080811 Inhibitor / Unkown
HY-124368 RB-042 Inhibitor / Unkown
HY-120268 SLM6031434 Inhibitor / Unkown
HY-184272 SphK2-IN-5 Inhibitor / Unkown
HY-183338 SphK2-IN-4 Inhibitor / Unkown
HY-12897 (R)-FTY720-OMe Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Sphk2 NCBI NCBI:56848