2. Gene
  3. Sphk2 - sphingosine kinase 2 Gene

Sphk2 - sphingosine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sk2; Spk2

Gene ID: 56632 | Gene type: protein coding

About Sphk2

Chromosome 7: 45,358,891-45,367,426 reverse strand.GRCm39:CM001000.3

This gene has 4 transcripts (splice variants), 209 orthologues, 4 paralogues and is associated with 5 phenotypes. Ubiquitous expression in duodenum adult (RPKM 72.1), adrenal adult (RPKM 42.9) and 28 other tissues.

Summary

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and Apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances Apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Sphk2 Products(3)

mRNA Protein Name
NM_203280.3 NP_975009.1 sphingosine kinase 2
NM_020011.5 NP_064395.2 sphingosine kinase 2
NM_001172561.1 NP_001166032.1 sphingosine kinase 2

Sphk2 Protein Structure

PLN02958

PLN02958: cl29912 (141 - 607)

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  • 617 a.a.
Protein Preferred Names Protein Names

sphingosine kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147282 Amgen-23 Inhibitor 99.00% Unkown
HY-148707 SphK1&2-IN-1 Inhibitor 99.33% Unkown
HY-150615 SphK1-IN-2 Inhibitor / Unkown
HY-151350 SphK2-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sphk2 NCBI NCBI:56848