SRSF7 - serine and arginine rich splicing factor 7 Gene

Also Known as 9G8; AAG3; SFRS7

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 6432

About SRSF7

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,743,599-38,751,494 (from NCBI)

This gene has 12 transcripts (splice variants), 232 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 57.8), lymph node (RPKM 43.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding Other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]

SRSF7 Products (3)

mRNA Protein Name
NM_001031684.3 NP_001026854.1 serine/arginine-rich splicing factor 7 isoform 1
NM_001195446.2 NP_001182375.1 serine/arginine-rich splicing factor 7 isoform 2
NM_001363802.1 NP_001350731.1 serine/arginine-rich splicing factor 7 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
10749975 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
10749975 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in RNA splicing IDA
IDA: Inferred from direct assay
8013463 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
15009664 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRSF7 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (13 - 77)

  • 0
  • 100
  • 200
  • 238 a.a.
Protein Preferred Names Protein Names

serine/arginine-rich splicing factor 7

  • SR splicing factor 7

SRSF7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SRSF7 Q16629 RBBP6 Homo sapiens Q7Z6E9
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 RBBP6 Homo sapiens Q7Z6E9
Anti Tag CoIP
18624398
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Y2H Array
31515488
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Y2H Prey Pooling
25416956
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
25416956
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
32296183
Intra
SRSF7 Q16629 LUC7L2 Homo sapiens Q9Y383
Y2H Array
25416956
Intra
SRSF7 Q16629 RNPS1 Homo sapiens Q15287
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 NXF1 Homo sapiens Q9UBU9
Pull Down
17036044
Intra
SRSF7 Q16629 NXF1 Homo sapiens Q9UBU9
CoIP
15184380
Intra
SRSF7 Q16629 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 SRPK1 Homo sapiens Q96SB4
Protein Kinase Assay
23602568
Intra
SRSF7 Q16629 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra
SRSF7 Q16629 LUC7L Homo sapiens Q9NQ29-3
Validated Y2H
32296183
Intra
SRSF7 Q16629 PRPF38A Homo sapiens Q8NAV1
Validated Y2H
32296183
Intra
SRSF7 Q16629 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
SRSF7 Q16629 SDCBP Homo sapiens O00560
Y2H Array
25416956
Cross
SRSF7 Q16629 Srek1 Rattus norvegicus Q9JKL7
Pull Down
14559993
Cross: Cross-species interaction Intra: Intraspecies interaction

SRSF7 抗体

製品番号 製品名 アプリケーション 反応性
HY-P811025 SRSF7 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

関連疾患

Diseases Alias
Allergic Bronchopulmonary Aspergillosis

  • Aspergillosis, Allergic Bronchopulmonary

  • Abpa

  • Allergic Bronchopulmonary Mycosis

  • Hinson-Pepys Disease

  • Pulmonary Aspergillus Disease

  • Allergic Aspergillosis

  • Aspergillosis Allergic Bronchopulmonary
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13798 SRSF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19484 Srsf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25977 Srsf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta SRSF7 VGNC VGNC:77822
Felis catus SRSF7 VGNC VGNC:81226
Canis familiaris SRSF7 VGNC VGNC:46821
Rattus norvegicus SRSF7 RGD RGD:1307425
Mus musculus SRSF7 MGD MGI:1926232
Bos taurus SRSF7 VGNC VGNC:35303
Others SRSF7 NCBI