GNE-555
GNE-555 is a selective, metabolically stable mTOR inhibitor (Ki=1.5 nM) that also has good oral bioavailability. GNE-555 exhibits antiproliferative activity on PC3 and MCF-7 cells and can be used in cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1428902-71-9
- 分子式: C26H34N6O3
- 分子量:478.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | EC50 |
75 nM
Compound: 20, GNE-555
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Cytotoxicity against human MCF7 neo/Her2 cells after 3 days by CellTiter-Glo assay
Cytotoxicity against human MCF7 neo/Her2 cells after 3 days by CellTiter-Glo assay
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[PMID: 23473235] |
| PC-3 | EC50 |
29 nM
Compound: 20, GNE-555
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Cytotoxicity against human PC3 cells after 4 days by CellTiter-Glo assay
Cytotoxicity against human PC3 cells after 4 days by CellTiter-Glo assay
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[PMID: 23473235] |
化学情報
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CAS 番号 1428902-71-9
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分子量 478.59
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分子式 C26H34N6O3
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SMILES
O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(C[C@]4([H])CC[C@@]5([H])N4C6COC6)C5=N2)C=C1)NCC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Estrada AA, et al. Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR). J Med Chem. 2013 Apr 11;56(7):3090-101. [Content Brief]
[2]. Huang G, et al. Applications of oxetanes in drug discovery and medicinal chemistry. Eur J Med Chem. 2023 Dec 5;261:115802. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GNE-555 関連分類
HY-13847 関連分類
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