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HDAC6-IN-45

HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability.

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  • CAS 番号: 3048532-05-1
  • 分子式: C23H24FN3O2
  • 分子量:393.45
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • HDAC6-IN-45 Chemical Structure
    HDAC6-IN-45 構造式
CAS 番号: 3048532-05-1
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  • HDAC6-IN-45 Chemical Structure
    HDAC6-IN-45 Chemical Structure
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  • HDAC6-IN-45