Heclin
Based on 3 publication(s) in Google Scholar
Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.00%
- CAS 番号: 890605-54-6
- 分子式: C17H17NO3
- 分子量:283.32
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Heclin
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IF
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IF
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IF
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生物活性
Heclin (10 μM, 1-5 days) inhibits cell viability and IGF1 signaling of BGC803 and MKN45 cell lines[1].
Heclin (7 μM, 1 h) ameliorates epinecidin-1-mediated MyD88 degradation in Raw264.7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BGC803 and MKN45 cells
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Concentration:10 μM
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Incubation Time:48 h
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Result:Reduced phosphorylation of Akt.
化学情報
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CAS 番号 890605-54-6
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性状 Solid
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分子量 283.32
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分子式 C17H17NO3
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Color Off-white to light brown
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SMILES
CC(C(C=C1)=CC=C1NC(/C=C/C2=CC=C(CC)O2)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Mol Cell
SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation. [Abstract]2023 Dec 7;83(23):4352-4369.e8. PMID: 38016474 -
Nat Chem Biol
2025 Apr;21(4):490-500. PMID: 39215100
Heclin purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr;21(4):490-500. [Abstract]
Heclin (25 μM; 1 h) delayed stress granule disassembly in cell lines including SHSY5Y and HeLa.
Heclin purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr;21(4):490-500. [Abstract]
Heclin (25 μM; 1 h) caused delayed SG disassembly in HEK293 cells at 120 min recovery.
Heclin purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr;21(4):490-500. [Abstract]
Heclin (25 μM; 1 h) caused heclin-treated HEK293 cells to display ～2-h delays in clearance.
Heclin purchased from MedChemExpress. Usage Cited in: Nat Chem Biol. 2025 Apr;21(4):490-500. [Abstract]
Heclin (25 μM; 1 h) decreased the overlap of K63-specific ubiquitination signals within granule areas of HEK293 cells.
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溶剤 & 溶解度
DMSO : 100 mg/mL (352.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (273 KB)
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- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Wang K, et al. Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer [J]. Oncogene, 2023, 42(14): 1072-1087. [Content Brief]
[2]. Su B C, Chen J Y. Antimicrobial peptide epinecidin-1 modulates MyD88 protein levels via the proteasome degradation pathway [J]. Marine Drugs, 2017, 15(11): 362. [Content Brief]
[3]. Mund T, et al. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases [J]. Proceedings of the National Academy of Sciences, 2014, 111(47): 16736-16741. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5296 mL | 17.6479 mL | 35.2958 mL | 88.2394 mL |
| 5 mM | 0.7059 mL | 3.5296 mL | 7.0592 mL | 17.6479 mL | |
| 10 mM | 0.3530 mL | 1.7648 mL | 3.5296 mL | 8.8239 mL | |
| 15 mM | 0.2353 mL | 1.1765 mL | 2.3531 mL | 5.8826 mL | |
| 20 mM | 0.1765 mL | 0.8824 mL | 1.7648 mL | 4.4120 mL | |
| 25 mM | 0.1412 mL | 0.7059 mL | 1.4118 mL | 3.5296 mL | |
| 30 mM | 0.1177 mL | 0.5883 mL | 1.1765 mL | 2.9413 mL | |
| 40 mM | 0.0882 mL | 0.4412 mL | 0.8824 mL | 2.2060 mL | |
| 50 mM | 0.0706 mL | 0.3530 mL | 0.7059 mL | 1.7648 mL | |
| 60 mM | 0.0588 mL | 0.2941 mL | 0.5883 mL | 1.4707 mL | |
| 80 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1030 mL | |
| 100 mM | 0.0353 mL | 0.1765 mL | 0.3530 mL | 0.8824 mL |
Heclin 関連分類
HY-110204 関連分類
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