Heptenophos
Heptenophos is an inhibitor of AChE and plasma carboxylesterase (CES). By inhibiting AChE activity, Heptenophos causes the accumulation of acetylcholine at cholinergic synapses, thereby triggering typical symptoms of organophosphate poisoning. Heptenophos exhibits rapid lethal toxicity in male albino mice, but its toxic effects are effectively antagonized by obidoxime, and Memantine (HY-B0591) further enhances the detoxification efficacy of obidoxime. Therefore, Heptenophos is commonly used in studies related to the mechanism of organophosphate poisoning and detoxification strategies.
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- CAS 番号: 23560-59-0
- 分子式: C9H12ClO4P
- 分子量:250.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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AChE |
The intravenous LD50 of Heptenophos in male albino mice is 196.68 μmol/kg. When administered in combination, obidoxime chloride (HY-W011108) at an ED50 of 21.56 μmol/kg is required to achieve a 50% survival rate (Heptenophos at 1.3 LD50; intravenous injection; single administration)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:albino mice (male, 18-24 g)[1]
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Dosage:1.3 LD50; 196.68 μmol/kg (LD50)
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Administration:i.v.; single dose
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Result:Induced severe inhibition of central, peripheral, and erythrocyte AChE as well as plasma carboxylesterase, leaving 3.33% of erythrocyte AChE, 3.37% of brain AChE, 13.05% of diaphragmal AChE, and 7.3% of plasma carboxylesterase activity uninhibited.
Reached an intravenous LD50 of 196.68 μmol/kg (95% confidence interval: 163.72-208.41).
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Animal Model:Albino mice (male, 18-24 g)[2]
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Dosage:1.3 LD50 (toxic challenge); 196.68 μmol/kg (LD50 determination)
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Administration:i.v.; single dose
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Result:Determined an intravenous LD50 of 196.68 μmol/kg (95% confidence interval: 163.72-208.41 μmol/kg).
Required an obidoxime ED50 of 21.56 μmol/kg to achieve 50% survival when administered concurrently with 1.3 LD50 heptenophos.
化学情報
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CAS 番号 23560-59-0
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分子量 250.61
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分子式 C9H12ClO4P
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SMILES
O=P(OC1=C(Cl)C2C=CCC12)(OC)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Heptenophos 関連分類
HY-120042 関連分類
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