country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-P4092

Copy Link Print Information

HN-1

HN-1 is a tumor-specific internalizing peptide. HN-1 internalizes through receptor-mediated, energy-dependent, Clathrin-mediated endocytosis. HN-1 preferentially binds to invasive head and neck squamous cell carcinoma and is selectively internalized. HN-1 enhances the transfer of liposome-DNA complexes to head and neck squamous cell carcinoma. HN-1 can be used for research on head and neck squamous cell carcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 386223-83-2
分子式: C₅₇H₉₆N₁₈O₁₈
分子量:1321.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

HN-1 構造式

CAS 番号: 386223-83-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

HN-1 is internalized by attached HNSCC cell lines such as MDA177Tu, UMSCC1, SCC-25, CAL-27, and FaDu, but not by suspended HNSCC cells or normal HOK16B/NOE/NHDF cells, via energy-dependent clathrin-mediated endocytosis and endosomal localization^[2].
HN-1 (>500 μM) blocks FITC-labeled HN-1 internal fluorescence in HNSCC cells, supporting specific HN-1-mediated uptake rather than free-dye labeling^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Anti-cancer

Cy5-labeled HN-1-PKCε is taken up by HNSCC xenograft tumors and reduces overall HNSCC tumor growth in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 386223-83-2
分子量 1321.48
分子式 C₅₇H₉₆N₁₈O₁₈
配列

Thr-Ser-Pro-Leu-Asn-Ile-His-Asn-Gly-Gln-Lys-Leu
シーケンスの短縮

TSPLNIHNGQKL
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hong FD, et al. Isolation of a peptide for targeted drug delivery into human head and neck solid tumors. Cancer Res. 2000 Dec 1;60(23):6551-6. PMID: 11118031. [Content Brief]

[2]. Hong FU, et al. Tumor specifically internalizing peptide 'HN-1': Targeting the putative receptor retinoblastoma-regulated discoidin domain receptor 1 involved in metastasis. World journal of clinical oncology. 2022 May 24;13(5):323-338.

[3]. Wright CL, et al. Advancing theranostics with tumor-targeting peptides for precision otolaryngology. World journal of otorhinolaryngology - head and neck surgery. 2016 Jun;2(2):98-108.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ