IB15C
IB15C is an ILT3 (LILRB4) inhibitor with a human Kd of 0.92 μM. IB15C binds to a specific ILT3 pocket, disrupts ApoE interaction, and interferes with downstream inhibitory signaling pathways. IB15C reduces SHP1 and SHP2 phosphorylation, suppresses pro-inflammatory cytokine secretion, enhances amyloid uptake, and attenuates NF-κB activation. IB15C can be used for the research of alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C21H25N3O4
- 分子量:383.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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LILRB 0.92 μM (Kd) |
IB15C binds to recombinant human ILT3 extracellular domain with submicromolar affinity, showing an apparent Kd of 0.92 μM[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in an ELISA-based assay with an IC50 of 0.48 μM[1].
IB15C inhibits the interaction between recombinant human ILT3 extracellular domain and ApoE in a BLI-based real-time assay with an IC50 of 0.64 μM[1].
IB15C (1-10 μM) reverses ILT3-dependent inhibitory signaling, reduces inflammatory activation, and restores Aβ uptake in human iPSC-derived microglia under Aβ42- and ApoE-driven conditions, with no detectable cytotoxicity at concentrations up to 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 383.44
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分子式 C21H25N3O4
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SMILES
COC1=C(OC)C=CC(C(C)CNC(C2=CC(C(C(C)C)=NO3)=C3N=C2)=O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
IB15C 関連分類
HY-184157 関連分類
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