IMM-01
Based on 1 Customer Validation
IMM-01 is a mammalian Diaphanous (mDia)-related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.12%
- CAS 番号: 218795-74-5
- 分子式: C12H17N3O2S
- 分子量:267.35
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IMM-01 (100 μM; 1h) induces microtubule stabilization in SW480 colon carcinoma cells[1].
IMM-01 (10 μM) significantly induces LacZ expression in NIH 3T3-SRE-LacZ cells[1].
IMM-01 (1-100 μM; 48 hours) induces caspase-3 cleavage during induction of apoptosis in NIH 3T3 cells and SW480 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH 3T3 cells and SW480 cells
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Concentration:1 μM, 10 μM, or 100 μM
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Incubation Time:48 hours
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Result:Induced caspase-3 cleavage.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic nude female mice (6 to 8 weeks) implanted with SW480 cells[1]
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Dosage:5 mg/kg, 25 mg/kg
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Administration:i.v.; 2 times a week; for 3 weeks
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Result:Slowed tumor growth in a dose-dependent manner when administered intravenously via the tail vein.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 218795-74-5
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性状 Solid
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分子量 267.35
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分子式 C12H17N3O2S
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Color Light yellow to light brown
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SMILES
OC1=CC=C(/C=N/NC(NC(C)(C)C)=S)C(O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 125 mg/mL (467.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7404 mL | 18.7021 mL | 37.4042 mL | 93.5104 mL |
| 5 mM | 0.7481 mL | 3.7404 mL | 7.4808 mL | 18.7021 mL | |
| 10 mM | 0.3740 mL | 1.8702 mL | 3.7404 mL | 9.3510 mL | |
| 15 mM | 0.2494 mL | 1.2468 mL | 2.4936 mL | 6.2340 mL | |
| 20 mM | 0.1870 mL | 0.9351 mL | 1.8702 mL | 4.6755 mL | |
| 25 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7404 mL | |
| 30 mM | 0.1247 mL | 0.6234 mL | 1.2468 mL | 3.1170 mL | |
| 40 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
| 50 mM | 0.0748 mL | 0.3740 mL | 0.7481 mL | 1.8702 mL | |
| 60 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5585 mL | |
| 80 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL | |
| 100 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9351 mL |
IMM-01 関連分類
HY-124808 関連分類
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