Inaxaplin
Based on 1 Customer Validation
Inaxaplin (VX-147) is an orally active apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.44%
- CAS 番号: 2446816-88-0
- 分子式: C21H18F3N3O3
- 分子量:417.38
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Clinical Compound Library
HY-L026
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Drug Repurposing Compound Library
HY-L035
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Orally Active Compound Library
HY-L061
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Heterocyclic Compound Library
HY-L138
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Drug Repurposing Compound Library Plus
HY-L035P
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Clinical Compound Library Plus
HY-L026P
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
APOL1[1]
Inaxaplin is an apolipoprotein L1 function inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2446816-88-0
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性状 Solid
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分子量 417.38
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分子式 C21H18F3N3O3
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Color White to off-white
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SMILES
O[C@H](CNC1=O)[C@@H]1NC(CCC(C2=CC(F)=C3)=C(C4=CC=C(C=C4)F)NC2=C3F)=O
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別名
VX-147
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (119.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. WO2020131807
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3959 mL | 11.9795 mL | 23.9590 mL | 59.8975 mL |
| 5 mM | 0.4792 mL | 2.3959 mL | 4.7918 mL | 11.9795 mL | |
| 10 mM | 0.2396 mL | 1.1979 mL | 2.3959 mL | 5.9897 mL | |
| 15 mM | 0.1597 mL | 0.7986 mL | 1.5973 mL | 3.9932 mL | |
| 20 mM | 0.1198 mL | 0.5990 mL | 1.1979 mL | 2.9949 mL | |
| 25 mM | 0.0958 mL | 0.4792 mL | 0.9584 mL | 2.3959 mL | |
| 30 mM | 0.0799 mL | 0.3993 mL | 0.7986 mL | 1.9966 mL | |
| 40 mM | 0.0599 mL | 0.2995 mL | 0.5990 mL | 1.4974 mL | |
| 50 mM | 0.0479 mL | 0.2396 mL | 0.4792 mL | 1.1979 mL | |
| 60 mM | 0.0399 mL | 0.1997 mL | 0.3993 mL | 0.9983 mL | |
| 80 mM | 0.0299 mL | 0.1497 mL | 0.2995 mL | 0.7487 mL | |
| 100 mM | 0.0240 mL | 0.1198 mL | 0.2396 mL | 0.5990 mL |
Inaxaplin 関連分類
HY-132820 関連分類
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