ISD sodium
Based on 4 publication(s) in Google Scholar
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the cGAS‑STING‑TBK1‑IRF3 pathway.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.02%
- 分子量:27674.92 (free acid)
-
保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 ISD sodium
More
生物活性
ISD (2 μg/mL; 2-4 h) sodium activates the cGAS-STING pathway in bone marrow-derived macrophages, promotes the phosphorylation of STING and IRF3, and upregulates the mRNA expression of IFN-β, TNF-α, IL-6 and CXCL10[1].
ISD (8 μg per well; 6 h) sodium induces IFNB promoter activity mediated by the cGAS-STING signaling pathway in HeLa cells[2].
ISD (8 μg per well; 6 h) sodium induces the mRNA expression of Ifna4, Ifnb, Isg15 and Rsad2 in L929 cells/mouse bone marrow-derived macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:L929 murine fibroblast cells
-
Concentration:8 μg per well
-
Incubation Time:6 h
-
Result:Triggered induction of Ifna4, Ifnb, Isg15, and Rsad2 mRNA in L929 cells.
化学情報
-
性状 Solid
-
分子量 27674.92 (free acid)
-
Color White to off-white
-
SMILES
[ISD (sodium)]
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
Adv Sci (Weinh)
RNF213 Is an Interferon-Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection. [Abstract]2026 Mar 18:e11012. PMID: 41849692 -
Chin Herb Med
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. [Abstract]2024 Apr 30;16(3):422-434. PMID: 39072201 -
Int Immunopharmacol
2025 Feb 6:147:114014. PMID: 39793225 -
Immunopharmacol Immunotoxicol
Dichapetalin-type triterpenoids inhibits macrophage interferon expression by regulating the cGas-STING pathway, suggesting potential application in immunosuppression. [Abstract]2025 Aug;47(4):517-524. PMID: 40443028
純度とドキュメンテーション
-
データシート (270 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2242 KB)
参考文献
[1]. Li J, et al. Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. Chin Herb Med. 2024 Apr 30;16(3):422-434. [Content Brief]
[2]. Xu L, et al. Laminaran potentiates cGAS-STING signaling to enhance antiviral responses. Int Immunopharmacol. 2025;147:114014. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ISD sodium 関連分類
HY-160225 関連分類
Powered by Bioz