Isoxanthopterin
Based on 1 Customer Validation
Isoxanthopterin is a pteridine marker used to indicate xanthine oxidase activity. Isoxanthopterin is used in research on type 1 diabetes, breast cancer, and hyperphenylalaninemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.85%
- CAS 番号: 529-69-1
- 分子式: C6H5N5O2
- 分子量:179.14
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
The UV-vis spectrum of Isoxanthopterin (50 μM) shows absorption maxima at 282 and 340.01 nm, which are attributed to π→π and n→π transitions[3].
Isoxanthopterin effectively supports the growth of Alcaligenes faecalis as a sole nitrogen source[5].
Isoxanthopterin (7.8-250 μM; 24 h) exhibits cytotoxicity against confluent MCF-7 human mammary carcinoma cells, with IC50 values of 109 μM (full-range least squares fit), 119 μM (62.5-250 μM range), and 103 μM (abstract), as measured by the MTS assay[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:MCF-7
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Concentration:7.8-500 μM
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Incubation Time:24 h
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Result:Exhibited cytotoxicity against MCF-7 human breast cancer cells.
化学情報
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CAS 番号 529-69-1
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性状 Solid
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分子量 179.14
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分子式 C6H5N5O2
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Color Light yellow to brown
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SMILES
O=C1C(N=C2)=C(NC(N)=N1)NC2=O
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Structure Classification
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Initial Source
Morpho sulkowskyi
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
H2O : 9.09 mg/mL (50.74 mM; Need ultrasonic)
H2O : 4.17 mg/mL (23.28 mM; ultrasonic and warming and adjust pH to 12 with 1 M NaOH and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
純度とドキュメンテーション
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データシート (282 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / H2O | 1 mM | 5.5822 mL | 27.9111 mL | 55.8223 mL | 139.5557 mL |
| 5 mM | 1.1164 mL | 5.5822 mL | 11.1645 mL | 27.9111 mL | |
| 10 mM | 0.5582 mL | 2.7911 mL | 5.5822 mL | 13.9556 mL | |
| 15 mM | 0.3721 mL | 1.8607 mL | 3.7215 mL | 9.3037 mL | |
| 20 mM | 0.2791 mL | 1.3956 mL | 2.7911 mL | 6.9778 mL | |
| H2O | 25 mM | 0.2233 mL | 1.1164 mL | 2.2329 mL | 5.5822 mL |
| 30 mM | 0.1861 mL | 0.9304 mL | 1.8607 mL | 4.6519 mL | |
| 40 mM | 0.1396 mL | 0.6978 mL | 1.3956 mL | 3.4889 mL | |
| 50 mM | 0.1116 mL | 0.5582 mL | 1.1164 mL | 2.7911 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Isoxanthopterin 関連分類
HY-W016568 関連分類
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