JD-02
JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C23H32N6O2
- 分子量:424.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
JD-02 (0-2 μM, 24, 48, and 72 h) inhibits growth and in HTC116 and SW620 cells[1].
JD-02 (1 μM, 36 h) induces G0/G1 phase arrest in HTC116 and SW620 cells[1].
JD-02 (1 μM, 48 h) induces cell apoptosis in HTC116 and SW620 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HTC116 and SW620 cells
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Concentration:0–2 μM
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Incubation Time:24, 48, and 72 h
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Result:Inhibited cell growth.
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Cell Line:HTC116 and SW620 cells
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Concentration:1 μM
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Incubation Time:48 h.
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Result:Induced cell apoptosis.
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Cell Line:HTC116 and SW620 cells
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Concentration:1 μM
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Incubation Time:36 h
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Result:Induced G0/G1 phase arrest.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HCT116 cell xenograft mouse model[1]
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Dosage:5, 10, and 20 mg/kg
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Administration:Intravenous injection for 21 days
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Result:decreased tumor development by 64.3%.
化学情報
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分子量 424.54
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分子式 C23H32N6O2
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SMILES
CC1=NN(C2=CC=C(C(N)=O)C(N[C@@H]3CC[C@@H](O)CC3)=C2)C4=C1/C(CC(C)(C)C4)=N/N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JD-02 関連分類
HY-162365 関連分類
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