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製品番号: HY-169634

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JD118

Name: JD118
Brand: MedChemExpress
SKU: HY-169634
Price: 137.00 USD
Availability: InStock
Rating: 5 (1 reviews)

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 315704-83-7
分子式: C₁₃H₁₂N₄S₂
分子量:288.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JD118 構造式

CAS 番号: 315704-83-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

JD118 is a JNK inhibitor. JD118 inhibits JNK1 activity and the expression of cJun (1–135)^[1].

JNK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	44 μM Compound: 7	Antiproliferative activity against MCF7 cells after 72 hrs Antiproliferative activity against MCF7 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	55 μM Compound: 7	Antiproliferative activity against SkBr3 cells after 72 hrs Antiproliferative activity against SkBr3 cells after 72 hrs	[PMID: 17223347]
SK-BR-3	IC₅₀	61 μM Compound: 7	Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA Induction of Hsp90-dependent Her2 protein degradation in Skbr3 cells after 24 hrs by ELISA	[PMID: 17223347]

化学情報

CAS 番号 315704-83-7
分子量 288.39
分子式 C₁₃H₁₂N₄S₂
SMILES

CC1=C(SC(N)=N1)C2=CSC(NC3=CC=CC=C3)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ngoei KR, et al. Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochim Biophys Acta. 2013;1834(6):1077-1088. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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