K-14585
K-14585 is a peptide competitive PAR2 antagonist. K-14585 inhibits PAR2-dependent IL-8 production, NF-κB phosphorylation, and p38 signaling. K-14585 reduces SLIGKV (PAR2 agonist peptide)-induced Ca2+ mobilisation in primary human keratinocytes.
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- CAS 番号: 880546-17-8
- 分子式: C51H56Cl2N8O4
- 分子量:915.95
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PAR2 |
化学情報
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CAS 番号 880546-17-8
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分子量 915.95
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分子式 C51H56Cl2N8O4
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SMILES
ClC(C=CC=C1Cl)=C1CN2C(C(C(CN3CCCC3)=C2)=C4)=CC=C4NC(NCC(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=CC=C5)C(NC(C6=CC=CC=C6)C7=CC=CC=C7)=O)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Goh FG, et al. Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling. Br J Pharmacol. 2009 Dec;158(7):1695-704. [Content Brief]
[2]. Kanke T, et al. Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo. Br J Pharmacol. 2009 Sep;158(1):361-71. [Content Brief]
[3]. Sevigny LM, et al. Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8491-6. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
K-14585 関連分類
HY-111214 関連分類
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