KF20274
KF20274 is an orally active adenosine A1 receptor antagonist. KF20274 increases the fecal pellet output in rats, and does not affect small intestinal propulsion or gastric emptying at defecation-increasing doses. KF20274 does not induce diarrhea at defecation-increasing doses. KF20274 can be used for the research of constipation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 143394-68-7
- 分子式: C21H29N5O
- 分子量:367.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
A1AR |
体内実験
KF20274 (0.01-3 mg/kg; p.o.) does not alter small intestinal propulsion, gastric emptying in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 150-250 g)[1]
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Dosage:0.0003, 0.001, 0.003, 0.01, 0.03 mg/kg
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Administration:p.o.
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Result:Increased fecal wet weight and dry weight.
Maintained fecal water content at 51-55%.
Resulted in 0/10 incidence of diarrhea across all tested doses.
化学情報
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CAS 番号 143394-68-7
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分子量 367.49
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分子式 C21H29N5O
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SMILES
CCCN1C2=C(C3=N[C@H](CC)CN3C1=O)NC(C45C6CC(CC(C6)C5)C4)=N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KF20274 関連分類
HY-182340 関連分類
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