L-97-1
L-97-1 is a A1 adenosine receptor (A1AR) antagonist. L-97-1 is a water-soluble small molecule compound with high affinity and high selectivity against human A1 adenosine receptors. L-97-1 works by blocking A1 adenosine receptors. In patients with asthma, adenosine is an important signaling molecule capable of causing bronchoconstriction by activating A1AR. L-97-1 reduces airway hyperreactivity (BHR) by competitively binding to A1AR, thereby alleviating or blocking adenosine-induced bronchoconstriction and inflammation.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 770703-20-3
- 分子式: C29H38N6O3
- 分子量:518.65
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
化学情報
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CAS 番号 770703-20-3
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分子量 518.65
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分子式 C29H38N6O3
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SMILES
O=C(N1CCC)N(CCC2=CC=C(N)C=C2)C3=C(N(CCN(CC)CCO)C(CC4=CC=CC=C4)=N3)C1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Obiefuna P C M, et al. A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3, 7-dihydro-purine-2, 6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 315(1): 329-336. [Content Brief]
Calculators
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L-97-1 関連分類
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