L-NIO
Based on 2 publication(s) in Google Scholar
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO induces a consistentfocal ischemic infarctin rats.
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- CAS 番号: 36889-13-1
- 分子式: C7H15N3O2
- 分子量:173.21
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 L-NIO
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生物活性
Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1]
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Cell Line
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Type | Value | Description | References |
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| RAW | IC50 |
9 μM
Compound: L-NIO
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Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.
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[PMID: 9873655] |
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 36889-13-1
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分子量 173.21
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分子式 C7H15N3O2
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SMILES
CC(NCCC[C@@H](C(O)=O)N)=N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Mol Gastroenterol Hepatol
2021;11(3):683-696. PMID: 33075564 -
Eur J Pharmacol
Bradykinin modulates endothelin-1-enhanced and monocrotaline-induced pulmonary arterial hypertension-associated arrhythmogenesis in rabbit right ventricular outflow tract via a nitric oxide-dependent pathway. [Abstract]2026 Apr 24:178896. PMID: 42035941
純度とドキュメンテーション
参考文献
[1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [Content Brief]
[2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
L-NIO 関連分類
HY-100986B 関連分類
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