LG190155
LG190155 is a nonsteroidal vitamin D receptor (VDR) agonist. LG190155 activates VDR in mesenchymal stem cells, thereby upregulating the BMP6-IL6 autocrine axis. Pretreatment of mesenchymal stem cells with LG190155 significantly enhances their ability to induce differentiation of acute myeloid leukemia cells, without inducing hypercalcemia. LG190155 is applicable to research related to acute myeloid leukemia (AML).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 233268-78-5
- 分子式: C31H44O4
- 分子量:480.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
16.9 μM
Compound: LG190155
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Antipoliferative activity against human Caco2 cells after 48 hrs by MTT assay
Antipoliferative activity against human Caco2 cells after 48 hrs by MTT assay
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[PMID: 26562542] |
| HEK293 | IC50 |
>10 μM
Compound: 5a, 5c, LG190155
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Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay
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[PMID: 23462715] |
| HepG2 | IC50 |
>50 μM
Compound: LG190155
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Antipoliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antipoliferative activity against human HepG2 cells after 48 hrs by MTT assay
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[PMID: 26562542] |
| HL-60 | EC50 |
0.59 μM
Compound: LG190155
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Agonist activity at vitamin D3 receptor in human HL-60 cells assessed as induction of cell differentiation after 96 hrs by NBT dye-based microscopic analysis
Agonist activity at vitamin D3 receptor in human HL-60 cells assessed as induction of cell differentiation after 96 hrs by NBT dye-based microscopic analysis
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[PMID: 26562542] |
| HL-60 | EC50 |
30 nM
Compound: 5a, 5c, LG190155
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Induction of monocytic cell differentiation in human HL60 cells
Induction of monocytic cell differentiation in human HL60 cells
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[PMID: 23462715] |
| HL-60 | ED50 |
410 nM
Compound: 1
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Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation
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[PMID: 16019211] |
| L02 | IC50 |
5.1 μM
Compound: LG190155
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Cytotoxicity against human L02 cells after 48 hrs by MTT assay
Cytotoxicity against human L02 cells after 48 hrs by MTT assay
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[PMID: 26562542] |
| LNCaP | EC50 |
20 nM
Compound: 5a, 5c, LG190155
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Growth inhibition of human LNCAP cells
Growth inhibition of human LNCAP cells
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[PMID: 23462715] |
| MCF7 | IC50 |
7.8 μM
Compound: LG190155
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Antipoliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antipoliferative activity against human MCF7 cells after 48 hrs by MTT assay
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[PMID: 26562542] |
| PC-3 | IC50 |
>50 μM
Compound: LG190155
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Antipoliferative activity against human PC3 cells after 48 hrs by MTT assay
Antipoliferative activity against human PC3 cells after 48 hrs by MTT assay
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[PMID: 26562542] |
| SC-3 | IC50 |
1900 nM
Compound: 1
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Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation
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[PMID: 16019211] |
体外実験
Treatment of human umbilical cord mesenchymal stem cells (LMSC) with LG190155 (2-8 µM, 24 h) enhances the ability of LMSC to induce differentiation of AML cells, and this effect is not caused by the cytotoxicity of LG190155 itself against MSC[1].
LG190155 drives BMP6 gene transcription and autocrine signaling by activating VDR in MSCs, thereby enhancing the synthesis and secretion of IL-6[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 233268-78-5
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分子量 480.68
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分子式 C31H44O4
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SMILES
CCC(C1=CC=C(C(C)=C1)OCC(C(C)(C)C)=O)(CC)C2=CC=C(C(C)=C2)OCC(C(C)(C)C)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LG190155 関連分類
HY-118970 関連分類
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