LW106
LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2116519-76-5
- 分子式: C11H11N5O2
- 分子量:245.24
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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IDO1 1.57 μM (IC50) |
LW106 (12.5-200 μM) does not affect proliferation of three types of tumor cells (HeLa, Lewis, B16F10 cells) with different expression levels of IDO1[1].
LW106 restores the function of CD8+ T cells by blocking the activity of IDO1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis and B16F10 tumors model established in 57BL6 mice, athymic nude mice or Ido1-/- mice[1]
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Dosage:20, 40 and 80 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 18 days
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Result:Dose-dependently inhibited tumor growth of Lewis lung cancer or B16F10 melanoma. Reconstructed the tumor immune microenvironment, enhanced anti-tumor immunity, and inhibited stromal cells and cancer stem cells. Inhibited tumor proliferation, promoted apoptosis, and reduced the matrix barrier.
Inhibited the self-renewal ability of cancer stem cells.
化学情報
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CAS 番号 2116519-76-5
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分子量 245.24
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分子式 C11H11N5O2
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SMILES
O/N=C(N1CC2=C(C1)C=CC=C2)/C3=NON=C3N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LW106 関連分類
HY-134920 関連分類
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