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製品番号: HY-156073

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LY3325656

Name: LY3325656
Brand: MedChemExpress
SKU: HY-156073
Price: 395.00 USD
Availability: InStock
Rating: 5 (1 reviews)

LY3325656 is a selective GPR142 receptor agonist. LY3325656 selectively activates GPR142 in humans and mice. LY3325656 enhances glucose-dependent insulin secretion, glucagon secretion, as well as the secretion of incretin hormones GLP-1 and GIP. LY3325656 can be used in research related to type 2 diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1998714-25-2
分子式: C₂₁H₂₃F₃N₆O₂
分子量:448.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

LY3325656 構造式

CAS 番号: 1998714-25-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- Parmacokinetics
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]

GPR142

GLP-1

GIP

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	43 nM Compound: 21; LY3325656	Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1-d2 addition by HTRF assay	[PMID: 31982234]

体外実験

LY3325656 (compound 21) (30 min) exhibits low metabolic turnover with mouse, rat, dog, and human liver microsomes, with turnover rates of 22%, 14%, 13%, and 14% respectively^[1].
LY3325656 (10 μM) inhibits CYP 3A4, CYP 2C9, and CYP 2D6 enzymes by 22%, 11%, and 16% respectively at a concentration of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Parmacokinetics

Species	Dose	Route	CL	V_ss	F
Rat^[1]	1 mg/kg	i.v.	22.1 mL/min/kg	1.1 L/kg	/
Rat^[1]	10 mg/kg	p.o.	/	/	63 %
Dog^[1]	1 mg/kg	i.v.	8.4 mL/min/kg	1.3 L/kg	/
Dog^[1]	5 mg/kg	p.o.	/	/	78 %

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

化学情報

CAS 番号 1998714-25-2
分子量 448.45
分子式 C₂₁H₂₃F₃N₆O₂
SMILES

CC1=C(N(C)C=N1)C=2NC(=NN2)[C@@H]3C[C@H](N(C(=O)C4=CC(C(F)(F)F)=CC=C4)C)CCO3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liu LZ, et al. Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human. Bioorganic & medicinal chemistry letters. 2020 Mar 01;30(5):126857. [Content Brief]

[2]. Pratt EJ, et al. 20‑OR: GPR142 Agonists Increase Glucose‑Dependent Insulin Secretion and Differentially Regulate Hormone Secretion in Preclinical and Phase 1 Studies. Diabetes. 2019;68(Suppl 1):20‑OR.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献

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LY3325656

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