MC4171
Based on 2 publication(s) in Google Scholar
MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 µM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.37%
- CAS 番号: 3034769-78-0
- 分子式: C21H15N3O3
- 分子量:357.36
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 MC4171
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生物活性
KAT8[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
33 μM
Compound: 34; MC4171
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Antiproliferative activity against human A549 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| HCT-116 | IC50 |
46.6 μM
Compound: 34; MC4171
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Antiproliferative activity against human HCT-116 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| HT-29 | IC50 |
54 μM
Compound: 34; MC4171
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Antiproliferative activity against human HT-29 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| NCI-H1299 | IC50 |
41.6 μM
Compound: 34; MC4171
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Antiproliferative activity against human NCI-H1299 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| U-937 | IC50 |
51.7 μM
Compound: 34; MC4171
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Antiproliferative activity against human U-937 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
化学情報
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CAS 番号 3034769-78-0
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性状 Solid
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分子量 357.36
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分子式 C21H15N3O3
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Color Brown to orange
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SMILES
O=C(O)C1=CC=C(N2N=C(C3=CC=CC=C3)/C(C2=O)=C/C4=CC=CN4)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance. [Abstract]2025 Aug 5;322(Pt 1):146571. PMID: 40769364 -
Commun Biol
MOF-mediated H4K16ac is critical for blastocyst formation in sheep by shaping promoter accessibility and transcription. [Abstract]2026 Mar 17;9(1):609. PMID: 41844839
溶剤 & 溶解度
DMSO : 25 mg/mL (69.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7983 mL | 13.9915 mL | 27.9830 mL | 69.9575 mL |
| 5 mM | 0.5597 mL | 2.7983 mL | 5.5966 mL | 13.9915 mL | |
| 10 mM | 0.2798 mL | 1.3991 mL | 2.7983 mL | 6.9957 mL | |
| 15 mM | 0.1866 mL | 0.9328 mL | 1.8655 mL | 4.6638 mL | |
| 20 mM | 0.1399 mL | 0.6996 mL | 1.3991 mL | 3.4979 mL | |
| 25 mM | 0.1119 mL | 0.5597 mL | 1.1193 mL | 2.7983 mL | |
| 30 mM | 0.0933 mL | 0.4664 mL | 0.9328 mL | 2.3319 mL | |
| 40 mM | 0.0700 mL | 0.3498 mL | 0.6996 mL | 1.7489 mL | |
| 50 mM | 0.0560 mL | 0.2798 mL | 0.5597 mL | 1.3991 mL | |
| 60 mM | 0.0466 mL | 0.2332 mL | 0.4664 mL | 1.1660 mL |
MC4171 関連分類
HY-153604 関連分類
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