Moprolol
Moprolol ((±)-Moprolol) is an beta-adrenergic receptor blocker, which can be used for research in essential hypertension.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 5741-22-0
- 分子式: C13H21NO3
- 分子量:239.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Adrenergic Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[2]|
Beta-1 adrenergic receptor |
体外実験
l-Moprolol is a β-blocker L-enantiomer with low negative inotropic activity and mild intrinsic sympathetomimetic activity, which can be used effectively in systemic hypertension studies. In primary open Angle glaucoma (POAG) or ocular hypertension (OHT) models, the topical application of l-Moprolol can reduce intraocular pressure (IOP) as effectively as tiolol, and has emerged as a promising compound for the inhibition of glaucoma due to its lack of activity on bronchial muscles[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 5741-22-0
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分子量 239.31
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分子式 C13H21NO3
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SMILES
OC(CNC(C)C)COC1=CC=CC=C1OC
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別名
(±)-Moprolol
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Borowiecki P, et al. Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol. RSC Adv. 2022 Aug 10;12(34):22150-22160. [Content Brief]
[2]. Liu J, et al. beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clin Pharmacol Ther. 2006 Jul;80(1):23-32. [Content Brief]
[3]. Rossetti L, et al. The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):670-4. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Moprolol 関連分類
HY-108306 関連分類
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