Morphothiadin mesylate
Based on 7 publication(s) in Google Scholar
Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir (HY-B1826)-resistant HBV replication with an IC50 value of 12 nM.
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- CAS 番号: 1646361-04-7
- 分子式: C22H26BrFN4O6S2
- 分子量:605.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Morphothiadin mesylate
More- Cell Mol Gastroenterol Hepatol. 2022;13(4):1001-1017. [Abstract]
- Emerg Microbes Infect. 2021 Dec;10(1):37-50. [Abstract]
- PLoS Pathog. 2025 Aug 5;21(8):e1013391. [Abstract]
- PLoS Pathog. 2021 Aug 9;17(8):e1009838. [Abstract]
- J Virol. 2026 May 14:e0003526. [Abstract]
- J Virol. 2022 Nov 9;96(21):e0136222. [Abstract]
- Anal Methods. 2022 Jan 6;14(2):135-146. [Abstract]
生物活性
製品説明
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1646361-04-7
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分子量 605.50
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分子式 C22H26BrFN4O6S2
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SMILES
O=C(C1=C(CN2CCOCC2)N=C(C3=NC=CS3)NC1C4=CC=C(C=C4Br)F)OCC.O=S(O)(C)=O
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別名
GLS4 mesylate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Cell Mol Gastroenterol Hepatol
2022;13(4):1001-1017. PMID: 34896285 -
Emerg Microbes Infect
Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection. [Abstract]2021 Dec;10(1):37-50. PMID: 33296295 -
PLoS Pathog
HBV capsid assembly modulators differentially modulate the assembly of wild-type and drug-resistant core protein chimeric nucleocapsids and empty capsids. [Abstract]2025 Aug 5;21(8):e1013391. PMID: 40763308 -
PLoS Pathog
Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes. [Abstract]2021 Aug 9;17(8):e1009838. PMID: 34370796 -
J Virol
Generation of HBV cccDNA using single-stranded M13 phage DNA for authentic minichromosome functionality. [Abstract]2026 May 14:e0003526. PMID: 42132423 -
J Virol
Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation. [Abstract]2022 Nov 9;96(21):e0136222. PMID: 36226986 -
Anal Methods
An automated microfluidic platform for the screening and characterization of novel hepatitis B virus capsid assembly modulators. [Abstract]2022 Jan 6;14(2):135-146. PMID: 34918017
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
[1]. Zhou X, et al. Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs. Acta Pharmacol Sin. 2013 Nov;34(11):1420-6. [Content Brief]
[2]. Wu G, et al. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 2013 Nov;57(11):5344-54. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Morphothiadin mesylate 関連分類
HY-108917A 関連分類
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