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製品番号: HY-124130

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MX106

MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein.

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CAS 番号: 2170836-81-2
分子式: C₂₅H₃₀N₂O₂
分子量:390.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MX106 構造式

CAS 番号: 2170836-81-2

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	1 μM Compound: MX-106	Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
MDA-MB-435	IC₅₀	2.1 μM Compound: MX-106	Antiproliferative activity against human MDA-MB-435/LCC6MDR cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-435/LCC6MDR cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
MDA-MB-435	IC₅₀	3.5 μM Compound: MX-106	Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
MDA-MB-453	IC₅₀	1.6 μM Compound: MX-106	Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
RPMI-7951	IC₅₀	1.1 μM Compound: MX-106	Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
SK-BR-3	IC₅₀	2.3 μM Compound: MX-106	Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]

体外実験

MX106 (0.03 nM-1 μM; 72 h) inhibits proliferation of human melanoma, epidermoid carcinoma, and colon cancer cells, with greater potency against P-glycoprotein-overexpressing multidrug-resistant cell lines, and exhibits an IC₅₀ as low as 0.03 μM against SW620/Ad300 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A375, WM164, M14, M14/MDR1, KB-3-1, KB-C2, SW620, SW620/Ad300
Concentration:

0.03 nM-1 μM; 0.9 μM (A375); 1.1 μM (WM164); 0.8 μM (M14); 1.8 μM (M14/MDR1); 1.25 μM (KB-3-1); 0.33 μM (KB-C2); 0.15 μM (SW620); 0.03 μM (SW620/Ad300)
Incubation Time:

72 h
Result:

Inhibited proliferation of A375 cells with an IC₅₀ of 0.9 ± 0.1 μM.
Inhibited proliferation of WM164 cells with an IC₅₀ of 1.1 ± 0.2 μM.
Inhibited proliferation of M14 cells with an IC₅₀ of 0.8 ± 0.2 μM.
Inhibited proliferation of M14/MDR1 cells with an IC₅₀ of 1.8 ± 0.4 μM, showing 2.3-fold resistance compared to parental M14 cells.
Inhibited proliferation of KB-3-1 cells with an IC₅₀ of 1.25 ± 0.10 μM.
Inhibited proliferation of KB-C2 cells with an IC₅₀ of 0.33 ± 0.12 μM, showing 3.8-fold greater potency compared to parental KB-3-1 cells.
Inhibited proliferation of SW620 cells with an IC₅₀ of 0.15 ± 0.01 μM.
Inhibited proliferation of SW620/Ad300 cells with an IC₅₀ of 0.03 ± 0.01 μM, showing 5-fold greater potency compared to parental SW620 cells.

Related Protocols :

化学情報

CAS 番号 2170836-81-2
分子量 390.53
分子式 C₂₅H₃₀N₂O₂
SMILES

OC1=C2N=CC=CC2=C(C=C1CN3CCCC3)COCC4=CC=C(C=C4)C(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Wang Q, et al. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. Eur J Med Chem. 2018;149:211-224. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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