4,4'-Di-O-methylellagic acid
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light. 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway.
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- CAS 番号: 3374-77-4
- 分子式: C16H10O8
- 分子量:330.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythrocyte | IC50 |
1.1 mM
Compound: 9
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Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
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[PMID: 29631958] |
| Erythrocyte | IC50 |
1.31 mM
Compound: 9
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Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
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[PMID: 29631958] |
化学情報
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CAS 番号 3374-77-4
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分子量 330.25
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分子式 C16H10O8
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SMILES
O=C1C2=CC(OC)=C(O)C(O3)=C2C4=C(C3=O)C=C(OC)C(O)=C4O1
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別名
4,4'-DiOMEA; Nasutin C
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Structure Classification
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Initial Source
Nasutitermes exitiosus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. B. P. MOORE, et al. Coumarin-like Substances from Australian Termites. Nature. 1962.
[2]. Ana Ramírez de Molina, et al. The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16. J Pharmacol Exp Ther. 2015, 353, 2. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
4,4'-Di-O-methylellagic acid 関連分類
HY-N7171 関連分類
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