Nitidanin
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 171674-89-8
- 分子式: C21H24O8
- 分子量:404.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh7.5.1 | CC50 |
464.4 μM
Compound: 21
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Cytotoxicity against human Huh7.5.1 cells after 72 hrs by ATPlite assay
Cytotoxicity against human Huh7.5.1 cells after 72 hrs by ATPlite assay
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[PMID: 30485098] |
| KB | ED50 |
>99 μM
Compound: 4
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Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
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[PMID: 16562832] |
Nitidanin shows inhibitory effects to D6 and W2 clones of Plasmodium falciparum with IC50 values of 21.2 and 18.4 μM, respectively[1]. Nitidanin shows noncytotoxic effects to human oral epidermoid carcinoma (KB) cells with an EC50 value ＞99 μM[1]. Nitidanin shows low cytotoxic effect to human hepatoma Huh7.5.1 cells with an CC50 value of 464.4 μM[2]. Nitidanin (0-250 μM; 5 hours) shows anti-HCV activity with an IC50 value of 200 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 171674-89-8
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分子量 404.41
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分子式 C21H24O8
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SMILES
OC[C@@H]1OC2=C(OC)C=C(/C=C/CO)C=C2O[C@H]1C3=CC(OC)=C(O)C(OC)=C3
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別名
(±)-Nitidanin
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50. [Content Brief]
[2]. Pilkington LI, et al. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles. J Nat Prod. 2018 Dec 28;81(12):2630-2637. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Nitidanin 関連分類
HY-120104 関連分類
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