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製品番号: HY-189119

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NMI-1182

NMI-1182 is a nitric oxide-releasing prodrug of Naproxen (HY-15030). NMI-1182 is an orally active COX-1 and COX-2 inhibitor. NMI-1182 inhibits constitutive COX-1-mediated and inducible COX-2-mediated prostaglandin synthesis. NMI-1182 induces nitric oxide donor release, activating soluble guanylate cyclase to synthesize cGMP, causing vasodilation. NMI-1182 can be used for research on inflammation and pain.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 646509-43-5
分子式: C₁₇H₁₈N₂O₉
分子量:394.33

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

NMI-1182 構造式

CAS 番号: 646509-43-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

^[1]^[2]

COX-1

COX-2

COX アイソフォーム固有の製品をすべて表示 :

体外実験

Local Vascular RegulationInnate ImmunityLipid Inflammatory Mediators

Local Vascular Regulation

NMI-1182 inhibits COX-1 and COX-2 in human whole blood^[1].
NMI-1182 is a potent NO donor in LLC-PK1 cells, inducing cGMP at concentrations as low as 3 nM^[1].
NMI-1182 inhibits COX-1 and COX-2 activity in human whole blood, with −log IC₅₀ values of 4.71 and 5.05 for COX-1 and COX-2, respectively^[2].

Innate Immunity

NMI-1182 (70 μM; 15 min) induces cGMP synthesis in human hepatocytes^[1].

Lipid Inflammatory Mediators

Local Vascular Regulation

NMI-1182 (1 nM-10 µM) produces concentration-dependent vasodilation in isolated rat aorta^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Innate ImmunityLipid Inflammatory Mediators

Innate Immunity

NMI-1182 (10 mg/kg; oral; single administration 1 h before Carrageenan (HY-125474)) exhibited anti-inflammatory activity in Carrageenan-induced paw edema rats^[2].

Lipid Inflammatory Mediators

Innate Immunity

NMI-1182 (5 mg/kg; oral; single administration 1 h before Carrageenan injection) significantly reduced leukocyte infiltration and decreased PGE₂ levels by 90% in Carrageenan-induced air pouch inflammation rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (Male, 180-220 g, fasted)^[2]
Dosage:

10 mg/kg
Administration:

p.o.; single dose 1 h prior to Carrageenan
Result:

Showed comparable inhibition of paw oedema of between 50 and 65% at 3 h post-insult.

Animal Model:

Sprague-Dawley rats (Male, 180-220 g)^[2]
Dosage:

5 mg/kg
Administration:

p.o.; single dose 1 h prior to Carrageenan
Result:

Significantly reduced Carrageenan-induced leukocyte influx.
Significantly reduced PGE₂ levels in the exudates by 90%.

Related Protocols :

Research Protocol for Inflammation-related Diseases

化学情報

CAS 番号 646509-43-5
分子量 394.33
分子式 C₁₇H₁₈N₂O₉
SMILES

O=C(OC[C@@H](O[N+]([O-])=O)CO[N+]([O-])=O)[C@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Young DV, et al. A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods. Biochemical pharmacology. 2005 Nov 01;70(9):1343-51.

[2]. Ellis JL, et al. NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor. Inflammopharmacology. 2005;12(5-6):521-34.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
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- 体内実験
化学情報
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参考文献

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NMI-1182

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IC₅₀ & Target

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NMI-1182

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IC50 & Target

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体内実験

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NMI-1182 関連分類

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