Ochnaflavone
Based on 1 Customer Validation
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC50 of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC50 of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.30%
- CAS 番号: 50276-96-5
- 分子式: C30H18O10
- 分子量:538.46
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Phospholipase アイソフォーム固有の製品をすべて表示
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生物活性
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sPLA2 3.45 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>100 μM
Compound: ochanflavone
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Inhibition of human cloned cPLA2 expressed in HEK293 cells
Inhibition of human cloned cPLA2 expressed in HEK293 cells
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[PMID: 17826099] |
| HEK293 | IC50 |
>100 μM
Compound: ochanflavone
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Inhibition of human cloned sPLA2-10 expressed in HEK293 cells
Inhibition of human cloned sPLA2-10 expressed in HEK293 cells
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[PMID: 17826099] |
| HEK293 | IC50 |
>100 μM
Compound: ochanflavone
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Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells
Inhibition of rat cloned sPLA2-1B expressed in HEK293 cells
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[PMID: 17826099] |
| HEK293 | IC50 |
17.6 μM
Compound: ochanflavone
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Inhibition of human cloned sPLA2-5 expressed in HEK293 cells
Inhibition of human cloned sPLA2-5 expressed in HEK293 cells
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[PMID: 17826099] |
| HEK293 | IC50 |
3.5 μM
Compound: Ochnaflavone
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Inhibition of sPLA2-2A in HEK293 cell
Inhibition of sPLA2-2A in HEK293 cell
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[PMID: 16504502] |
| MCF7 | IC50 |
54.5 μM
Compound: 3
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Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay
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[PMID: 34875389] |
化学情報
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CAS 番号 50276-96-5
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性状 Solid
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分子量 538.46
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分子式 C30H18O10
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Color Yellow to brown
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SMILES
O=C1C=C(C2=CC=C(OC3=CC(C4=CC(C5=C(O)C=C(O)C=C5O4)=O)=CC=C3O)C=C2)OC6=CC(O)=CC(O)=C16
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 100 mg/mL (185.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8571 mL | 9.2857 mL | 18.5715 mL | 46.4287 mL |
| 5 mM | 0.3714 mL | 1.8571 mL | 3.7143 mL | 9.2857 mL | |
| 10 mM | 0.1857 mL | 0.9286 mL | 1.8571 mL | 4.6429 mL | |
| 15 mM | 0.1238 mL | 0.6190 mL | 1.2381 mL | 3.0952 mL | |
| 20 mM | 0.0929 mL | 0.4643 mL | 0.9286 mL | 2.3214 mL | |
| 25 mM | 0.0743 mL | 0.3714 mL | 0.7429 mL | 1.8571 mL | |
| 30 mM | 0.0619 mL | 0.3095 mL | 0.6190 mL | 1.5476 mL | |
| 40 mM | 0.0464 mL | 0.2321 mL | 0.4643 mL | 1.1607 mL | |
| 50 mM | 0.0371 mL | 0.1857 mL | 0.3714 mL | 0.9286 mL | |
| 60 mM | 0.0310 mL | 0.1548 mL | 0.3095 mL | 0.7738 mL | |
| 80 mM | 0.0232 mL | 0.1161 mL | 0.2321 mL | 0.5804 mL | |
| 100 mM | 0.0186 mL | 0.0929 mL | 0.1857 mL | 0.4643 mL |
Ochnaflavone 関連分類
HY-N7327 関連分類
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