Peluntamig
Based on 1 Customer Validation
Peluntamig (PT-217) is a bispecific antibody targeting DLL3 and CD47. The antibody arms of Peluntamig specifically bind to DLL3 on small cell lung cancer tumor cells while blocking the CD47-SIRPa interaction, thereby effectively stimulating macrophage phagocytosis and inducing NK cell-mediated cytotoxicity. Peluntamig exhibits significant anti-tumor activity against small cell lung cancer and also has favorable safety profiles. Peluntamig can be used in a variety of tumor-related studies including those on small cell lung cancer and L1210 leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 2928515-21-1
- 分子量:145.027 kDa
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Human IgG1 kappa
Human
CD47 & DLL3
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 × DBA/2 F1 (BDF1) (male, injected intraperitoneally with 106 L1210 leukemia cells on day 0)[2]
-
Dosage:15 mg/kg
-
Administration:i.p.; single injection; day 3 post-tumor cell inoculation
-
Result:Produced a percent increase in life span (% ILS) that contributed to an additive predicted % ILS for the triple combination (Peluntamig+cyclophosphamide + 5-fluorouracil).
Yielded an observed % ILS significantly exceeding the additive predicted value (p < 0.001) when used in the triple combination.
Resulted in 7 cures (≥60-day survival) out of 10 treated mice in the triple combination.
Caused a +2% mean weight change 5 days post-treatment when administered alone.
Caused a -9% mean weight change 5 days post-treatment in the triple combination.
Led to no toxic deaths in any treatment group.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Q61735-1 & Q9NYJ7
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
IgG1-kappa
ELISA, FACS, Functional assay
-
Immobilized Delta-like protein 3/DLL3 Protein, Human (HEK293, His, HY-P700456) can bind Peluntamig. The EC50 for this effect is 19.78 ng/mL. -
Immobilized CD47 Protein, Human (HEK293, His, HY-P7336) can bind Peluntamig. The EC50 for this effect is 187.6 ng/mL.
化学情報
-
CAS 番号 2928515-21-1
-
性状 Liquid
-
分子量 145.027 kDa
-
Color Colorless to light yellow
-
SMILES
[Peluntamig]
-
別名
PT-217
-
輸送条件
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
-
データシート (260 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)