Phylloflavan
Phylloflavan is an antileishmanial (Antileishmanial) agent with an EC50 of 3.2 nM against intracellular amastigotes of Leishmania donovani. Phylloflavan is isolated from Phyllocldus plants. Phylloflavan induces moderate levels of NO release. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblasts (38 U/mL).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 98570-83-3
- 分子式: C26H26O10
- 分子量:498.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
Leishmania donovani 3.2 nM (EC50) |
体外実験
Phylloflavan (50 μg/mL and serial two-fold dilutions; 72 h) potently inhibits intracellular Leishmania donovani amastigote survival in RAW 264.7 cells with an EC50 of 3.2 nM, while lacking cytotoxicity against host cells and activity against extracellular promastigotes[1].
Phylloflavan (50 μg/mL; 48 h) induces moderate nitric oxide release from RAW 264.7 cells[1].
Phylloflavan (50 μg/mL; 48 h) induces IFN-like activity in RAW 264.7 cells, resulting in 38 U/mL of cytoprotective activity against EMCV-induced cytopathic effect on L929 fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 98570-83-3
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分子量 498.48
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分子式 C26H26O10
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SMILES
O=C(C[C@@H](O)CCC1=CC(O)=C(O)C=C1)O[C@H]2CC3=C(O)C=C(O)C=C3O[C@@H]2C4=CC(O)=C(O)C=C4
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Phylloflavan 関連分類
HY-134467 関連分類
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