Picoplatin
Based on 1 Customer Validation
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.5%
- CAS 番号: 181630-15-9
- 分子式: C6H10Cl2N2Pt
- 分子量:376.15
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 181630-15-9
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性状 Solid
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分子量 376.15
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分子式 C6H10Cl2N2Pt
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Color Light yellow to yellow
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SMILES
[Cl-][Pt+2]([N]1=C(C)C=CC=C1)([NH3])[Cl-]
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別名
AMD473; ZD0473
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMF : 25 mg/mL (66.46 mM; Need ultrasonic; DMSO can inactivate Picoplatin's activity)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
純度とドキュメンテーション
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データシート (270 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.6585 mL | 13.2926 mL | 26.5851 mL | 66.4628 mL |
| 5 mM | 0.5317 mL | 2.6585 mL | 5.3170 mL | 13.2926 mL | |
| 10 mM | 0.2659 mL | 1.3293 mL | 2.6585 mL | 6.6463 mL | |
| 15 mM | 0.1772 mL | 0.8862 mL | 1.7723 mL | 4.4309 mL | |
| 20 mM | 0.1329 mL | 0.6646 mL | 1.3293 mL | 3.3231 mL | |
| 25 mM | 0.1063 mL | 0.5317 mL | 1.0634 mL | 2.6585 mL | |
| 30 mM | 0.0886 mL | 0.4431 mL | 0.8862 mL | 2.2154 mL | |
| 40 mM | 0.0665 mL | 0.3323 mL | 0.6646 mL | 1.6616 mL | |
| 50 mM | 0.0532 mL | 0.2659 mL | 0.5317 mL | 1.3293 mL | |
| 60 mM | 0.0443 mL | 0.2215 mL | 0.4431 mL | 1.1077 mL |
Picoplatin 関連分類
HY-131468 関連分類
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