Picumast
Picumast (Auteral; BM 15100) is an orally active antiallergic agent with histamine receptor antagonistic activity. Picumast inhibits allergy-related cascade reactions by suppressing mediator release from tissue mast cells while exerting histamine antagonistic effects. Picumast inhibits allergic reactions in rats, guinea pigs, and cynomolgus monkeys. Picumast can be used in allergy-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 39577-20-3
- 分子式: C25H31Cl3N2O3
- 分子量:513.88
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Histamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Picumast (BM 15100) dose-dependently inhibits labelled histamine uptake by isolated human leucocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Picumast (0.1‑0.8 mg/kg; p.o.) inhibits active cutaneous anaphylaxis (ACA) reactions in cynomolgus monkeys, with a significant inhibitory effect observed at the dose of 0.1 mg/kg[1].
Picumast (0.75 mg/kg; p.o.) inhibits allergic conjunctivitis and hyperemia symptoms in guinea pigs[1].
Picumast (0.4 mg/kg; p.o.) inhibits allergic bronchospasm in guinea pigs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 39577-20-3
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分子量 513.88
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分子式 C25H31Cl3N2O3
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SMILES
O=C1OC2=C(C(C)=C1C)C=CC(OCCCN3CCN(CC3)CC4=CC=C(C=C4)Cl)=C2.Cl.Cl
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別名
Auteral; BM 15100
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Picumast 関連分類
HY-106706 関連分類
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