(+)-Epiloliolide
Based on 1 Customer Validation
(+)-Epiloliolide is a megastigmane that can be isolated from Annona muricata. (+)-epiloliolide increased the nuclear localization of p53. (+)-Epiloliolide has anti-inflammatory effect through upregulating phosphorylation of the PKA/CREB pathway. (+)-Epiloliolide also effectively increases the proliferation and migration of human periodontal ligament cells by downregulating NLRP3 activated by PG-LPS.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95.0%
- CAS 番号: 38274-00-9
- 分子式: C11H16O3
- 分子量:196.24
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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NLRP3 |
化学情報
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CAS 番号 38274-00-9
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性状 Solid
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分子量 196.24
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分子式 C11H16O3
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Color Off-white to light yellow
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SMILES
C[C@@]12C(C(C)(C[C@@H](C1)O)C)=CC(O2)=O
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別名
Isololiolide
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Matsushige A, et al. Three new megastigmanes from the leaves of Annona muricata. J Nat Med. 2012 Apr;66(2):284-91. [Content Brief]
[2]. Chung Y, Jeong S, Lee IK, et al. Regulation of p53 Activity by (+)-Epiloliolide Isolated from Ulva lactuca. Mar Drugs. 2021;19(8):450. [Content Brief]
[3]. Kim EN, Nabende WY, Jeong H, Hahn D, Jeong GS. The Marine-Derived Natural Product Epiloliolide Isolated from Sargassum horneri Regulates NLRP3 via PKA/CREB, Promoting Proliferation and Anti-Inflammatory Effects of Human Periodontal Ligament Cells. Mar Drugs. 2021;19(7):388. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(+)-Epiloliolide 関連分類
HY-N10173 関連分類
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